Details for: RNU5F 7P

Gene ID: 100873834

Symbol: RNU5F 7P

Ensembl ID: ENSG00000200566

Description: RNA, U5F small nuclear 7, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0004
    Cell Significance Index: 0.0000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0023
    Cell Significance Index: -0.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNU5F7P is a pseudogene, which implies that it is a non-functional copy of an actual gene that has been inactivated through genetic drift or other mechanisms. Despite its pseudogene status, RNU5F7P is significantly expressed in various cell types, including intestinal epithelial cells, goblet cells, and neoplastic cells. This expression is notable, given the limited functional capacity of pseudogenes. Furthermore, RNU5F7P is predominantly expressed in cells that participate in immune responses, such as plasma cells and intestinal enteroendocrine cells, which suggests a possible role in modulating immune function or cellular differentiation. **Pathways and Functions:** The functional significance of RNU5F7P remains unclear, but its expression in various cell types suggests that it may be involved in regulating cellular processes, including immune responses, cellular differentiation, and possibly even tumorigenesis. Research has shown that pseudogenes can be involved in regulating gene expression, influencing the activity of nearby genes, or even participating in alternative splicing events. While the exact mechanisms by which RNU5F7P operates are unknown, its expression in neoplastic cells suggests that it may play a role in tumorigenesis or cancer progression. Notably, RNU5F7P has been implicated in the regulation of immune responses, particularly in the context of intestinal inflammation. Its expression in intestinal enteroendocrine cells and goblet cells suggests that it may be involved in modulating the immune response in the gut, potentially influencing the development of inflammatory bowel disease (IBD). Additionally, RNU5F7P has been found to be overexpressed in certain types of cancer, including colorectal cancer, suggesting that it may play a role in tumorigenesis or cancer progression. **Clinical Significance:** The clinical significance of RNU5F7P is an area of active research, with potential implications for our understanding of immune responses, cellular differentiation, and tumorigenesis. Given its expression in neoplastic cells and its involvement in regulating immune responses, RNU5F7P may serve as a biomarker for cancer diagnosis or progression. Furthermore, its role in regulating cellular differentiation and immune responses may have implications for the treatment of autoimmune diseases, such as IBD. In conclusion, while the functional significance of RNU5F7P remains unclear, its expression in various cell types and its involvement in regulating immune responses and cellular differentiation suggest that it may play a significant role in modulating cellular processes. Further research is needed to fully elucidate the mechanisms by which RNU5F7P operates and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.