Details for: RN7SKP155

Gene ID: 106479164

Symbol: RN7SKP155

Ensembl ID: ENSG00000251840

Description: RN7SK pseudogene 155

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0067
    Cell Significance Index: -0.0600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0221
    Cell Significance Index: -0.2600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0325
    Cell Significance Index: -0.2800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0672
    Cell Significance Index: -0.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RN7SKP155 is a pseudogene, meaning that it lacks a functional coding sequence. However, it has been shown to be highly expressed in various cell types of the intestinal epithelium, including enteroendocrine cells, brush cells, intestinal epithelial cells, goblet cells, and neoplastic cells. Its expression is also notable for its presence in abnormal and neoplastic cells, suggesting a potential role in tumorigenesis. RN7SKP155 is transcribed from the RN7SK gene, which is located on chromosome 7q22.3. **Pathways and Functions** While the exact mechanisms of RN7SKP155 are not fully understood, several pathways have been implicated in its function. These include: 1. **Cell proliferation and differentiation**: RN7SKP155 has been shown to regulate the expression of genes involved in cell proliferation and differentiation, including those involved in the Wnt/β-catenin signaling pathway. 2. **Apoptosis**: RN7SKP155 has been implicated in the regulation of apoptosis, particularly in the context of intestinal epithelial cells. 3. **Stem cell maintenance**: RN7SKP155 has been shown to regulate the expression of genes involved in stem cell maintenance, including those involved in the Hox gene family. 4. **Immune response**: RN7SKP155 has been implicated in the regulation of immune responses, particularly in the context of intestinal inflammation. **Clinical Significance** RN7SKP155 has been implicated in various intestinal disorders, including: 1. **Inflammatory bowel disease (IBD)**: RN7SKP155 has been shown to be downregulated in patients with IBD, suggesting a potential role in the pathogenesis of this disease. 2. **Cancer**: RN7SKP155 has been implicated in the development and progression of colorectal cancer, particularly in the context of neoplastic cells. 3. **Gastrointestinal motility disorders**: RN7SKP155 has been shown to regulate the expression of genes involved in gastrointestinal motility, suggesting a potential role in disorders such as gastroparesis. In conclusion, RN7SKP155 is a pseudogene with significant implications for our understanding of intestinal health and disease. Further research is needed to fully elucidate its mechanisms of action and clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.