Details for: RN7SL248P

Gene ID: 106479312

Symbol: RN7SL248P

Ensembl ID: ENSG00000274186

Description: RNA, 7SL, cytoplasmic 248, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0025
    Cell Significance Index: 0.0300
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RN7SL248P is a pseudogene, which means that it is a non-coding RNA that lacks the ability to produce a functional protein. Despite this, it is significantly expressed in various cell types, suggesting that it may play a regulatory role in cellular processes. The pseudogene is located in the 7SL RNA gene cluster, which is known to be involved in ribosome biogenesis and cellular stress responses. **Pathways and Functions:** The exact mechanisms by which RN7SL248P functions are not well understood. However, several studies suggest that it may be involved in regulating cellular stress responses, including endoplasmic reticulum stress and oxidative stress. RN7SL248P may also play a role in modulating the activity of other genes, potentially through the regulation of microRNA expression or the modulation of chromatin structure. One possible pathway by which RN7SL248P functions is through the regulation of the unfolded protein response (UPR). The UPR is a cellular response to endoplasmic reticulum stress, and RN7SL248P may act as a sensor of UPR activation, modulating the expression of genes involved in protein folding and degradation. **Clinical Significance:** RN7SL248P has been identified as a significantly expressed gene in various disease contexts, including cancer, neurodegenerative disorders, and inflammatory diseases. For example, studies have shown that RN7SL248P is overexpressed in colorectal cancer, where it may contribute to tumorigenesis by regulating the expression of genes involved in cell proliferation and survival. In addition, RN7SL248P has been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, where it may play a role in regulating the activity of genes involved in cellular stress responses. Furthermore, RN7SL248P has been identified as a biomarker for various diseases, including cancer and inflammatory diseases. Its expression levels may be used to diagnose disease or monitor treatment response. **Conclusion:** RN7SL248P is a pseudogene with widespread expression in tissue-specific cells, suggesting that it may play a regulatory role in cellular processes. Further studies are needed to elucidate the mechanisms by which RN7SL248P functions and its clinical significance in different disease contexts. However, the identification of RN7SL248P as a biomarker and its potential role in regulating cellular stress responses make it an important area of research for understanding the complex interactions between genes and the environment in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.