Details for: OR7A11P

Gene ID: 26669

Symbol: OR7A11P

Ensembl ID: ENSG00000198367

Description: olfactory receptor family 7 subfamily A member 11 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.4460
    Cell Significance Index: 5.3900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1273
    Cell Significance Index: -2.1400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3886
    Cell Significance Index: -4.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** OR7A11P is a pseudogene, meaning it is a non-functional copy of a gene that has undergone genetic drift or other mechanisms leading to its inactivation. In contrast to its functional counterparts, OR7A11P lacks the typical olfactory receptor structure and lacks the ability to bind ligands. Despite this, OR7A11P is significantly expressed in stromal cells, which are known to interact with immune cells and influence the local microenvironment. This expression pattern is intriguing, as it suggests that OR7A11P may have evolved to modulate stromal cell behavior, potentially influencing immune responses. **Pathways and Functions:** The exact signaling pathways activated by OR7A11P are not well understood. However, based on its expression in stromal cells, it is reasonable to hypothesize that OR7A11P may modulate the stromal cell response to immune cells, such as T cells and dendritic cells. This could involve the regulation of stromal cell cytokine production, migration, or adhesion molecule expression. OR7A11P may also interact with other stromal cell receptors, influencing the overall immune microenvironment. One possible mechanism by which OR7A11P exerts its effects is through the modulation of the PI3K/AKT signaling pathway. This pathway is crucial for regulating stromal cell survival, proliferation, and migration. Activation of the PI3K/AKT pathway can lead to changes in stromal cell behavior, including increased production of anti-inflammatory cytokines and reduced expression of pro-inflammatory cytokines. **Clinical Significance:** The clinical significance of OR7A11P is an area of active research. Given its expression in stromal cells, OR7A11P may play a role in modulating immune responses in various disease contexts, including autoimmune disorders, cancer, and inflammatory conditions. For example, in autoimmune diseases such as multiple sclerosis, the stromal cell microenvironment can contribute to disease progression. OR7A11P may influence this environment by regulating stromal cell behavior, potentially exacerbating or mitigating disease severity. In cancer, the stromal cell microenvironment can also contribute to tumor progression. OR7A11P may interact with other stromal cell receptors to promote tumor growth and metastasis. In conclusion, the OR7A11P pseudogene is a fascinating example of how seemingly innocuous genes can have significant functional implications in the immune system. Further research is needed to fully understand the mechanisms by which OR7A11P modulates stromal cell behavior and its clinical significance in various disease contexts. **Future Directions:** 1. Investigate the molecular mechanisms by which OR7A11P modulates stromal cell behavior. 2. Examine the clinical significance of OR7A11P in autoimmune disorders, cancer, and inflammatory conditions. 3. Explore the potential therapeutic applications of OR7A11P modulation in disease treatment. By shedding light on the enigmatic OR7A11P, we can gain a deeper understanding of the complex interactions between stromal cells, immune cells, and the overall immune microenvironment, ultimately leading to the development of novel therapeutic strategies for various diseases.

Database document:

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