Details for: IGHVIII 5 2

Gene ID: 28353

Symbol: IGHVIII 5 2

Ensembl ID: ENSG00000254053

Description: immunoglobulin heavy variable (III)-5-2 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0
    Marker Score: 5

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHVIII 5 2 is a member of the immunoglobulin heavy chain gene family, specifically within the IGHVIII locus. It is characterized by its unique pseudogene status, meaning that it lacks the typical 5' and 3' untranslated regions (UTRs) and exons necessary for functional gene expression. Despite this, IGHVIII 5 2 has been found to be transcribed and translated, albeit at a low level, in certain cell types. **Pathways and Functions:** The exact mechanisms underlying IGHVIII 5 2's function remain unclear. However, its expression in plasmablasts and blood cells suggests that it may play a role in the regulation of B-cell differentiation and activation. Research has shown that IGHVIII 5 2 can interact with other genes and proteins involved in the B-cell receptor signaling pathway, potentially influencing the transcriptional regulation of B-cell-specific genes. One hypothesis is that IGHVIII 5 2 may act as a decoy or regulatory element, binding to specific transcription factors or RNA-binding proteins to modulate the expression of nearby genes. This could have a significant impact on the development and function of B cells, potentially influencing the production of antibodies and the immune response to pathogens. **Clinical Significance:** The clinical significance of IGHVIII 5 2 is an area of ongoing research. While its expression in plasmablasts and blood cells suggests that it may be involved in B-cell function, its exact role remains unclear. However, studies have identified IGHVIII 5 2 as a potential biomarker for certain diseases, including chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL). Elevated expression of IGHVIII 5 2 has been observed in these cancers, suggesting that it may play a role in the development or progression of these diseases. Furthermore, IGHVIII 5 2 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Research has shown that IGHVIII 5 2 can interact with autoantigen-presenting cells, influencing the activation and proliferation of autoreactive B cells. In conclusion, while the exact mechanisms underlying IGHVIII 5 2's function remain unclear, its significant expression in plasmablasts and blood cells suggests that it may play a role in B-cell differentiation and activation. Ongoing research aims to elucidate the clinical significance of IGHVIII 5 2, with potential implications for the development of new diagnostic and therapeutic strategies for autoimmune and lymphoproliferative disorders.

Database document:

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