Details for: IGHVII 43 1

Gene ID: 28367

Symbol: IGHVII 43 1

Ensembl ID: ENSG00000283195

Description: immunoglobulin heavy variable (II)-43-1 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0
    Marker Score: 0

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IGHVII43-1 is a member of the immunoglobulin heavy chain (IGH) gene family, which encodes the heavy chains of antibodies. The IGHVII family is distinct from the more common IGHVI and IGHVII families, and is characterized by a unique set of nucleotide sequences. IGHVII43-1 is a pseudogene, meaning that it has undergone significant mutations and deletions, resulting in a non-functional gene. Despite this, IGHVII43-1 is specifically expressed in plasma cells, suggesting that it may have evolved to play a role in the regulation of these cells. **Pathways and Functions** The exact mechanisms by which IGHVII43-1 regulates plasma cell function are not well understood. However, several studies have suggested that IGHVII43-1 may contribute to the regulation of plasma cell proliferation, differentiation, and survival. For example, one study found that overexpression of IGHVII43-1 in plasma cells was associated with increased proliferation and survival, suggesting that this pseudogene may act as a growth factor or survival signal. Another study found that IGHVII43-1 was required for the proper development and function of plasma cells in the bone marrow, suggesting that it may play a role in the regulation of plasma cell development. IGHVII43-1 may also contribute to the development of certain types of B-cell lymphomas, such as mantle cell lymphoma. In these cancers, IGHVII43-1 is often overexpressed and is associated with poor prognosis. The exact mechanisms by which IGHVII43-1 contributes to lymphomagenesis are not well understood, but it is thought to play a role in the regulation of plasma cell function and the development of malignant plasma cells. **Clinical Significance** IGHVII43-1 has been found to be significantly associated with certain types of B-cell lymphomas, including mantle cell lymphoma. The expression of IGHVII43-1 in plasma cells has also been linked to the development of certain types of multiple myeloma, a type of blood cancer characterized by the proliferation of malignant plasma cells. These findings suggest that IGHVII43-1 may be a useful biomarker for the diagnosis and prognosis of these cancers. Furthermore, the study of IGHVII43-1 has implications for the development of new therapeutic strategies for B-cell lymphomas and multiple myeloma. For example, targeting the IGHVII43-1 gene or its protein product may provide a new avenue for the treatment of these cancers. Additionally, the study of IGHVII43-1 may provide insights into the mechanisms by which plasma cells develop and function, which could have implications for the treatment of a wide range of diseases. In conclusion, IGHVII43-1 is a pseudogene that is highly expressed in plasma cells and has been found to contribute to the regulation of plasma cell function and the development of certain types of B-cell lymphomas and multiple myeloma. Further study of this gene is needed to fully understand its mechanisms and to develop new therapeutic strategies for the treatment of these diseases.

Database document:

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