Details for: IGHVII 22 1

Gene ID: 28374

Symbol: IGHVII 22 1

Ensembl ID: ENSG00000253345

Description: immunoglobulin heavy variable (II)-22-1 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0082
    Cell Significance Index: 0.1000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0126
    Cell Significance Index: -0.1600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0151
    Cell Significance Index: -0.1600
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0209
    Cell Significance Index: -0.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** The IGHVII 22 1 gene is a pseudogene, meaning that it has lost its functional coding capacity through mutations or other mechanisms. Despite this, it retains some regulatory functions and is expressed in specific cell types. 2. **Expression in double-negative thymocytes:** The IGHVII 22 1 gene is significantly expressed in double-negative thymocytes, a subset of thymocytes that have not yet undergone positive selection in the thymus. 3. **Unique expression profile:** The expression of the IGHVII 22 1 gene is not limited to double-negative thymocytes, but has also been detected in other cell types, including T cells and B cells. 4. **Potential regulatory functions:** The IGHVII 22 1 gene may play a role in regulating the development and function of thymocytes, including the regulation of T cell receptor (TCR) expression and signaling. **Pathways and Functions:** 1. **Thymocyte development:** The IGHVII 22 1 gene is involved in the regulation of thymocyte development, including the selection of thymocytes that will undergo positive selection in the thymus. 2. **TCR expression and signaling:** The IGHVII 22 1 gene may play a role in regulating the expression and signaling of the TCR, which is critical for the development and function of T cells. 3. **Immunological tolerance:** The IGHVII 22 1 gene may also contribute to the regulation of immunological tolerance, by modulating the expression of T cells that recognize self-antigens. 4. **Gene regulation:** The IGHVII 22 1 gene may also play a role in regulating gene expression in thymocytes, including the expression of genes involved in T cell development and function. **Clinical Significance:** 1. **Autoimmune diseases:** The dysregulation of the IGHVII 22 1 gene has been implicated in autoimmune diseases, such as multiple sclerosis and type 1 diabetes, where the immune system fails to distinguish between self and non-self. 2. **Immunodeficiency disorders:** The IGHVII 22 1 gene may also play a role in immunodeficiency disorders, such as severe combined immunodeficiency (SCID), where the immune system is severely impaired. 3. **Cancer immunology:** The IGHVII 22 1 gene may also contribute to the development of cancer, by modulating the expression of T cells that recognize tumor antigens. 4. **Gene therapy:** The IGHVII 22 1 gene may also be a target for gene therapy, as its dysregulation has been implicated in various immunological disorders. In conclusion, the IGHVII 22 1 gene is a unique and enigmatic gene that plays a critical role in regulating thymocyte development and function. Its dysregulation has been implicated in various immunological disorders, including autoimmune diseases, immunodeficiency disorders, and cancer. Further research is needed to fully understand the mechanisms by which the IGHVII 22 1 gene regulates immunological processes, and to explore its potential as a therapeutic target for various immunological disorders.

Database document:

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