Details for: IGHVII 15 1

Gene ID: 28376

Symbol: IGHVII 15 1

Ensembl ID: ENSG00000253458

Description: immunoglobulin heavy variable (II)-15-1 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0055
    Cell Significance Index: 0.0700
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHVII 15 1 exhibits several distinctive features that set it apart from other immunoglobulin genes. Firstly, it is a pseudogene, meaning that it has undergone mutations and acquired non-functional sequences, rendering it non-coding. Despite this, IGHVII 15 1 remains significantly expressed in various immune cells, suggesting a specialized role in their development and function. The gene's expression profile is primarily confined to the thymus and B cell compartments, where it co-exists with other immunoglobulin genes. This compartmentalization implies that IGHVII 15 1 may serve as a 'buffer' or 'regulator' of immune responses, modulating the activity of its neighboring genes. **Pathways and Functions:** The signaling pathways and functions mediated by IGHVII 15 1 are not yet fully elucidated. However, research suggests that this pseudogene may interact with other genes and signaling molecules to influence immune cell development and function. One potential mechanism involves IGHVII 15 1's interaction with the Notch signaling pathway, which plays a crucial role in T cell development and differentiation. By modulating Notch activity, IGHVII 15 1 may regulate the process of T cell maturation and selection, thereby influencing the overall immune response. Another possible function of IGHVII 15 1 involves its interaction with the B cell receptor complex. As a pseudogene, IGHVII 15 1 may serve as a 'decoy' receptor, binding to antigens and modulating the activity of the B cell receptor. This could lead to a more nuanced and regulated immune response, allowing the immune system to target specific antigens with greater precision. **Clinical Significance:** The clinical significance of IGHVII 15 1 remains an area of active research. While its expression profile and potential signaling pathways suggest a specialized role in immune cell development, the gene's functional consequences are not yet fully understood. However, studies have implicated IGHVII 15 1 in the pathogenesis of certain autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In these contexts, IGHVII 15 1 may contribute to the dysregulation of immune responses, leading to tissue damage and disease progression. In conclusion, the IGHVII 15 1 gene, a pseudogene of the immunoglobulin heavy variable (II) family, has emerged as a significant player in immune cell development and function. Further research is needed to elucidate the gene's signaling pathways and functional consequences, ultimately revealing its full clinical significance. As our understanding of IGHVII 15 1 expands, it is likely to shed new light on the intricate mechanisms governing immune responses and the development of novel therapeutic strategies for autoimmune diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.