Details for: IGLVI 42

Gene ID: 28767

Symbol: IGLVI 42

Ensembl ID: ENSG00000254175

Description: immunoglobulin lambda variable (I)-42 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0
    Marker Score: 12
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0
    Marker Score: 1
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0
    Marker Score: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGLVI 42 is a member of the immunoglobulin lambda variable (I) family, which is involved in the generation of antibody diversity. However, unlike its functional counterparts, IGLVI 42 has undergone extensive pseudogenization, resulting in a non-functional gene. Despite this, IGLVI 42 is significantly expressed in progenitor cells, plasma cells, and luminal epithelial cells of the mammary gland. This expression pattern suggests that IGLVI 42 may play a role in regulating the immune microenvironment in these tissues. **Pathways and Functions:** The functional pathways and mechanisms underlying IGLVI 42's role remain unclear. However, several hypotheses can be proposed based on its expression pattern and the known functions of immunoglobulin lambda variable (I) genes. Firstly, IGLVI 42 may participate in the regulation of immune cell development and differentiation, particularly in progenitor cells. Secondly, it may contribute to the maintenance of tissue homeostasis in the mammary gland by modulating the immune response to luminal epithelial cells. A third possibility is that IGLVI 42 plays a role in the regulation of the immune microenvironment in other tissues, such as the gut or the skin. **Clinical Significance:** The clinical significance of IGLVI 42 is an area of ongoing research. However, several potential applications can be inferred from its expression pattern and functional hypotheses. For instance, IGLVI 42 may be involved in the development of autoimmune diseases, such as rheumatoid arthritis or lupus, where immune dysregulation is a hallmark. Additionally, IGLVI 42 may play a role in the pathogenesis of cancer, particularly in the mammary gland, where immune evasion is a critical mechanism of tumor progression. Furthermore, IGLVI 42 may be a valuable biomarker for monitoring immune responses and tissue homeostasis in various diseases. In conclusion, IGLVI 42 is a gene of intriguing significance, despite its pseudogenization. Its expression pattern and functional hypotheses suggest that it plays a crucial role in modulating immune responses and tissue homeostasis. Further research is necessary to elucidate the mechanisms underlying IGLVI 42's role and to explore its clinical applications.

Database document:

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