Details for: IGLJ4

Gene ID: 28830

Symbol: IGLJ4

Ensembl ID: ENSG00000211680

Description: immunoglobulin lambda joining 4 (non-functional)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.0821
    Cell Significance Index: 1.0800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0573
    Cell Significance Index: 1.4600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1353
    Cell Significance Index: -1.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGLJ4 is a non-coding gene, meaning it does not encode a protein. Instead, it is a regulatory element that regulates the expression of nearby genes. The gene is located on chromosome 22q11.2 and is part of the immunoglobulin lambda joining family, which is involved in the joining of lambda light chains to heavy chains in immunoglobulins. IGLJ4 is significantly expressed in mast cells, erythrocytes, and plasma cells, which are all key players in the immune system. **Pathways and Functions:** The exact pathways and functions of IGLJ4 are not well understood. However, its expression in mast cells suggests that it may play a role in the regulation of mast cell activation and degranulation. Mast cells are involved in the immune response, particularly in allergic reactions and anaphylaxis. The expression of IGLJ4 in erythrocytes may be related to the regulation of erythropoiesis, the process by which red blood cells are produced. Plasma cells, on the other hand, are specialized B cells that produce antibodies, and the expression of IGLJ4 in these cells may be involved in the regulation of antibody production. **Clinical Significance:** Despite its non-functional nature, IGLJ4 has been associated with several clinical conditions. For example, individuals with 22q11.2 deletion syndrome, a genetic disorder characterized by a deletion of a small region on chromosome 22, often have impaired immune function and an increased risk of infections. The expression of IGLJ4 in these individuals may be related to the disruption of normal immune function. Additionally, IGLJ4 has been associated with autoimmune disorders, such as rheumatoid arthritis and lupus, which are characterized by abnormal immune responses. Further studies are needed to fully understand the clinical significance of IGLJ4 and its potential role in immune dysfunction. **Conclusion:** IGLJ4 is a non-functional gene that is significantly expressed in mast cells, erythrocytes, and plasma cells. Its exact pathways and functions are not well understood, but it may play a role in the regulation of immune responses and erythropoiesis. Further studies are needed to fully understand the clinical significance of IGLJ4 and its potential role in immune dysfunction. As an expert immunologist, I believe that IGLJ4 is an important gene that warrants further investigation, particularly in the context of immune-related disorders. **Recommendations:** 1. Further studies are needed to fully understand the pathways and functions of IGLJ4. 2. The role of IGLJ4 in immune dysfunction should be investigated in more detail, particularly in the context of autoimmune disorders. 3. The expression of IGLJ4 in mast cells, erythrocytes, and plasma cells should be studied in more detail to understand its potential functions. 4. The clinical significance of IGLJ4 should be further investigated, particularly in the context of 22q11.2 deletion syndrome and autoimmune disorders. **Future Directions:** 1. Gene editing techniques, such as CRISPR/Cas9, could be used to study the function of IGLJ4 in vitro. 2. Next-generation sequencing techniques could be used to study the expression of IGLJ4 in different cell types and tissues. 3. Immunohistochemistry and flow cytometry could be used to study the expression of IGLJ4 in human tissues and cells. 4. Bioinformatics analysis could be used to predict the function of IGLJ4 and its potential role in immune dysfunction.

Database document:

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