Details for: IGKV2 19

Gene ID: 28925

Symbol: IGKV2 19

Ensembl ID: ENSG00000253732

Description: immunoglobulin kappa variable 2-19 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Unknown (CL0000003)
    Fold Change: 32.54
    Marker Score: 100,584
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.31
    Marker Score: 155,242
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 12.46
    Marker Score: 6,453
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 11.01
    Marker Score: 6,574
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.18
    Marker Score: 52,739
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.71
    Marker Score: 8,293
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.77
    Marker Score: 6,859
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.65
    Marker Score: 3,669
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,789
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.95
    Marker Score: 68,659
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.18
    Marker Score: 6,854
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.11
    Marker Score: 6,859

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IGKV2-19 is a pseudogene, which means that it has undergone significant mutations and deletions, resulting in a non-functional gene. However, unlike many pseudogenes, IGKV2-19 is significantly expressed in multiple cell types, suggesting that it may have evolved to play a specific role in the nervous system. The expression of IGKV2-19 is widespread, with significant expression observed in: * Glutamatergic neurons: a subtype of neurons that use glutamate as their neurotransmitter * Cajal-Retzius cells: a type of glial cell that plays a role in the development of the CNS * Cerebral cortex endothelial cells: cells that line the blood vessels in the cerebral cortex * Progenitor cells: cells that have the potential to differentiate into various cell types * Oligodendrocyte precursor cells: cells that give rise to oligodendrocytes, which are responsible for myelination in the CNS * Microglial cells: a type of glial cell that acts as a first line of defense against infection and injury in the CNS * Blood vessel endothelial cells: cells that line the blood vessels in the PNS * Forebrain radial glial cells: cells that play a role in the development of the forebrain * Cerebral cortex GABAergic interneurons: a subtype of interneurons that use gamma-aminobutyric acid (GABA) as their neurotransmitter **Pathways and Functions** The pathways and functions of IGKV2-19 are not yet fully understood, but several possibilities can be proposed based on its expression pattern: * IGKV2-19 may play a role in the development and maturation of neurons and glial cells, particularly in the CNS. * The gene may be involved in the regulation of gene expression, potentially through the modulation of transcription factor activity or the regulation of alternative splicing. * IGKV2-19 may also be involved in the regulation of signaling pathways, such as the PI3K/AKT pathway, which is important for cell survival and proliferation. * The gene may also play a role in the regulation of the immune response, particularly in the CNS, where it is expressed in microglial cells. **Clinical Significance** The clinical significance of IGKV2-19 is not yet fully understood, but several possibilities can be proposed based on its expression pattern: * IGKV2-19 may be involved in the development of neurological disorders, such as autism spectrum disorder, schizophrenia, or epilepsy, where there is evidence of abnormal expression of genes in the CNS. * The gene may also be involved in the regulation of the immune response in the CNS, which could have implications for the treatment of CNS infections or autoimmune disorders. * IGKV2-19 may also be used as a biomarker for the diagnosis or monitoring of neurological disorders, particularly in the CNS. In conclusion, IGKV2-19 is a pseudogene that is significantly expressed in various cell types within the CNS and PNS. While its function is not yet fully understood, its expression pattern suggests that it may play a role in the development and function of the nervous system. Further research is needed to fully understand the role of IGKV2-19 in the nervous system and its clinical significance.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.