Details for: MIRLET7A3

Gene ID: 406883

Symbol: MIRLET7A3

Ensembl ID: ENSG00000283990

Description: microRNA let-7a-3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0021
    Cell Significance Index: 0.0200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0013
    Cell Significance Index: -0.0100
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0013
    Cell Significance Index: -0.0100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0027
    Cell Significance Index: -0.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MIRLET7A3 is a 22-nucleotide long miRNA that belongs to the let-7 family, which is characterized by its conserved seed sequence (UGAG). This miRNA is significantly expressed in various cell types, including neuronal receptor cells, smooth muscle myoblasts, pericytes, lymphoid lineage-restricted progenitor cells, cardiac endothelial cells, cardiac muscle myoblasts, fibroblasts of cardiac tissue, and immature innate lymphoid cells. The expression of MIRLET7A3 is tightly regulated and is often associated with specific developmental stages and cellular processes. **Pathways and Functions:** MIRLET7A3 plays a crucial role in regulating gene expression through the miRNA-mediated post-transcriptional silencing pathway. This pathway involves the recognition of target messenger RNAs (mRNAs) by the RNA-induced silencing complex (RISC), which leads to the degradation of these mRNAs or inhibition of their translation. MIRLET7A3 has been shown to target various genes involved in cellular proliferation, differentiation, and survival, including those involved in immune and cardiovascular development. In the context of immune development, MIRLET7A3 has been implicated in the regulation of lymphoid lineage-restricted progenitor cells, where it targets genes involved in T-cell development and function. In cardiovascular development, MIRLET7A3 has been shown to regulate the expression of genes involved in cardiac cell differentiation and survival, including those involved in the development of cardiac muscle and endothelial cells. **Clinical Significance:** Abnormal expression of MIRLET7A3 has been associated with various diseases, including cancer, cardiovascular disease, and immune disorders. For example, reduced expression of MIRLET7A3 has been observed in certain types of cancer, such as colorectal and lung cancer, where it is associated with tumor progression and metastasis. Similarly, alterations in MIRLET7A3 expression have been linked to cardiovascular disease, including atherosclerosis and cardiac hypertrophy. In the context of immune disorders, MIRLET7A3 has been implicated in the regulation of immune cell development and function. For example, dysregulation of MIRLET7A3 expression has been observed in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it is associated with impaired immune tolerance and excessive inflammatory responses. In conclusion, MIRLET7A3 is a critical regulator of gene expression in various cellular contexts, including immune and cardiovascular development. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying its function and the potential therapeutic applications of targeting MIRLET7A3 in disease prevention and treatment.

Database document:

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