Details for: MIR135A1

Gene ID: 406925

Symbol: MIR135A1

Ensembl ID: ENSG00000207926

Description: microRNA 135a-1

Associated with

  • Cellular response to low-density lipoprotein particle stimulus
    (GO:0071404)
  • Cellular response to oxidative stress
    (GO:0034599)
  • Extracellular vesicle
    (GO:1903561)
  • Inflammatory response
    (GO:0006954)
  • Lncrna binding
    (GO:0106222)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of cytokine production involved in inflammatory response
    (GO:1900016)
  • Negative regulation of interleukin-17 production
    (GO:0032700)
  • Negative regulation of interleukin-17-mediated signaling pathway
    (GO:1903882)
  • Negative regulation of interleukin-17a production
    (GO:0150152)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4581
    Cell Significance Index: -5.7800
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.4994
    Cell Significance Index: -5.6700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.5155
    Cell Significance Index: -5.9000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.7719
    Cell Significance Index: -8.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MIR135A1 is a 22-nucleotide long microRNA that belongs to the MIR135 family. It is characterized by its ability to regulate gene expression post-transcriptionally by binding to complementary sequences on target messenger RNA (mRNA) molecules. MIR135A1 has been shown to target various genes involved in immune responses, including cytokines, chemokines, and transcription factors. Its expression is influenced by multiple factors, including oxidative stress, low-density lipoprotein particle stimulus, and extracellular vesicle-mediated signaling. **Pathways and Functions:** MIR135A1 participates in several key pathways, including: 1. **Cellular response to low-density lipoprotein particle stimulus:** MIR135A1 regulates the expression of genes involved in lipid metabolism and atherosclerosis. 2. **Cellular response to oxidative stress:** MIR135A1 modulates the expression of genes involved in antioxidant defense mechanisms. 3. **Extracellular vesicle-mediated signaling:** MIR135A1 regulates the expression of genes involved in vesicle formation and transport. 4. **Inflammatory response:** MIR135A1 negatively regulates cytokine production, interleukin-17 (IL-17) production, and IL-17-mediated signaling. 5. **RISC complex:** MIR135A1 interacts with the RNA-induced silencing complex (RISC) to facilitate microRNA-mediated gene silencing. **Clinical Significance:** MIR135A1 has been implicated in various diseases, including: 1. **Atherosclerosis:** MIR135A1 has been shown to regulate lipid metabolism and atherosclerosis development. 2. **Cancer:** MIR135A1 has been found to be overexpressed in several types of cancer, including lung, breast, and colon cancer. 3. **Autoimmune diseases:** MIR135A1 has been implicated in the regulation of immune responses and the development of autoimmune diseases, such as rheumatoid arthritis. 4. **Neurological disorders:** MIR135A1 has been found to be involved in the regulation of neuronal function and the development of neurological disorders, such as Alzheimer's disease. In conclusion, MIR135A1 is a critical regulator of immune responses and cellular stress. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of microRNA 135a-1 and its potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.