Details for: MIR148A

Gene ID: 406940

Symbol: MIR148A

Ensembl ID: ENSG00000199085

Description: microRNA 148a

Associated with

  • Cholesterol homeostasis
    (GO:0042632)
  • Extracellular space
    (GO:0005615)
  • Extracellular vesicle
    (GO:1903561)
  • Lipid homeostasis
    (GO:0055088)
  • Mirna-mediated gene silencing by inhibition of translation
    (GO:0035278)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of cholesterol efflux
    (GO:0090370)
  • Negative regulation of lipoprotein particle clearance
    (GO:0010985)
  • Negative regulation of lipoprotein transport
    (GO:0140076)
  • Negative regulation of low-density lipoprotein particle clearance
    (GO:0010989)
  • Negative regulation of low-density lipoprotein particle receptor binding
    (GO:1905596)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MIR148A is a 22-nucleotide long, single-stranded RNA that is highly conserved across species. It is expressed in various cell types, including neuronal receptor cells, smooth muscle myoblasts, and immune cells such as T cells and mast cells. MIR148A is known to target genes involved in cholesterol efflux, lipoprotein particle clearance, and lipid metabolism, suggesting its role in maintaining cholesterol homeostasis. **Pathways and Functions** MIR148A is involved in several key pathways, including: 1. **Cholesterol Homeostasis**: MIR148A targets genes involved in cholesterol efflux, such as ABCA1 and ABCG1, which are critical for removing excess cholesterol from cells. Downregulation of MIR148A leads to increased cholesterol efflux, while overexpression is associated with decreased cholesterol efflux. 2. **Lipid Metabolism**: MIR148A regulates genes involved in lipid synthesis and degradation, including SREBP1c and LPL. Dysregulation of MIR148A leads to altered lipid metabolism, contributing to the development of cardiovascular disease. 3. **Immune Response**: MIR148A targets genes involved in immune cell function, including T cell activation and cytokine production. Its dysregulation can lead to impaired immune responses, making it a potential therapeutic target for autoimmune diseases. 4. **Extracellular Vesicle Regulation**: MIR148A is involved in the regulation of extracellular vesicle formation and function, which is critical for intercellular communication. **Clinical Significance** Dysregulation of MIR148A has been implicated in various diseases, including: 1. **Cardiovascular Disease**: Altered MIR148A expression has been linked to increased risk of cardiovascular disease, including atherosclerosis and heart failure. 2. **Cancer**: MIR148A has been shown to target genes involved in cancer progression, including cell proliferation and metastasis. 3. **Autoimmune Diseases**: Dysregulation of MIR148A has been implicated in autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. In conclusion, MIR148A is a critical regulator of cholesterol homeostasis, lipid metabolism, and immune responses. Its dysregulation has significant clinical implications, making it a potential therapeutic target for various diseases. Further research is needed to fully elucidate the role of MIR148A in human disease and to explore its potential as a therapeutic agent.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.