Details for: MIR19B1

Gene ID: 406980

Symbol: MIR19B1

Ensembl ID: ENSG00000284375

Description: microRNA 19b-1

Associated with

  • Blood microparticle
    (GO:0072562)
  • Cardiac muscle cell fate commitment
    (GO:0060923)
  • Cellular response to bacterial lipopeptide
    (GO:0071221)
  • Cholesterol homeostasis
    (GO:0042632)
  • Extracellular space
    (GO:0005615)
  • Extracellular vesicle
    (GO:1903561)
  • Mirna-mediated gene silencing by inhibition of translation
    (GO:0035278)
  • Mirna-mediated gene silencing by mrna destabilization
    (GO:0035279)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of apolipoprotein a-i-mediated signaling pathway
    (GO:1905095)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of cardiac epithelial to mesenchymal transition
    (GO:0062044)
  • Negative regulation of cardiac muscle cell apoptotic process
    (GO:0010667)
  • Negative regulation of cell migration involved in sprouting angiogenesis
    (GO:0090051)
  • Negative regulation of cellular response to transforming growth factor beta stimulus
    (GO:1903845)
  • Negative regulation of cholesterol efflux
    (GO:0090370)
  • Negative regulation of coagulation
    (GO:0050819)
  • Negative regulation of extracellular matrix assembly
    (GO:1901202)
  • Negative regulation of fibroblast migration
    (GO:0010764)
  • Negative regulation of g2/m transition of mitotic cell cycle
    (GO:0010972)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of inflammatory response to antigenic stimulus
    (GO:0002862)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of matrix metallopeptidase secretion
    (GO:1904465)
  • Negative regulation of reverse cholesterol transport
    (GO:1903063)
  • Negative regulation of serine-type endopeptidase activity
    (GO:1900004)
  • Negative regulation of transforming growth factor beta receptor signaling pathway
    (GO:0030512)
  • Perinuclear region of cytoplasm
    (GO:0048471)
  • Positive regulation of apoptotic process involved in development
    (GO:1904747)
  • Positive regulation of cardiac muscle cell proliferation
    (GO:0060045)
  • Positive regulation of cell growth involved in cardiac muscle cell development
    (GO:0061051)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Regulation of plasma lipoprotein particle levels
    (GO:0097006)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0062
    Cell Significance Index: 0.0700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **MicroRNA**: MIR19B1 is a small non-coding RNA, approximately 22 nucleotides in length, which is a key characteristic of microRNAs (miRNAs). 2. **Regulatory function**: MIR19B1 regulates gene expression through post-transcriptional mechanisms, including inhibition of translation and mRNA destabilization. 3. **Tissue-specific expression**: MIR19B1 is significantly expressed in various cell types, including neuronal receptor cells, smooth muscle myoblasts, and cardiac muscle cells. 4. **Multiple pathways**: MIR19B1 is involved in numerous cellular pathways, including those related to cell proliferation, differentiation, survival, and apoptosis. **Pathways and Functions** 1. **Cellular response to bacterial lipopeptide**: MIR19B1 negatively regulates the cellular response to bacterial lipopeptides, suggesting its role in modulating immune responses. 2. **Cholesterol homeostasis**: MIR19B1 negatively regulates cholesterol efflux and reverse cholesterol transport, highlighting its role in maintaining lipid metabolism. 3. **Cardiac muscle cell fate commitment**: MIR19B1 positively regulates cardiac muscle cell proliferation and negatively regulates cardiac epithelial to mesenchymal transition, indicating its role in cardiac development and function. 4. **Negative regulation of various signaling pathways**: MIR19B1 negatively regulates numerous signaling pathways, including those involved in cell migration, apoptosis, and inflammatory responses. **Clinical Significance** 1. **Cardiovascular diseases**: Dysregulation of MIR19B1 expression has been linked to cardiovascular diseases, including heart failure and cardiac arrhythmias. 2. **Cancer**: MIR19B1 has been implicated in cancer development and progression, particularly in cardiac and smooth muscle tumors. 3. **Neurological disorders**: MIR19B1 expression has been altered in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Regenerative medicine**: MIR19B1 may play a role in tissue regeneration and repair, particularly in cardiac and smooth muscle tissues. In conclusion, MIR19B1 is a multifunctional microRNA that regulates various cellular processes, including cell proliferation, differentiation, and survival. Its dysregulation has been implicated in various diseases, highlighting the importance of MIR19B1 in maintaining cellular homeostasis and tissue function. Further research is needed to fully elucidate the role of MIR19B1 in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.