Details for: MIR200A

Gene ID: 406983

Symbol: MIR200A

Ensembl ID: ENSG00000207607

Description: microRNA 200a

Associated with

  • Cellular response to amyloid-beta
    (GO:1904646)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Positive regulation of blood vessel endothelial cell migration
    (GO:0043536)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.5754
    Cell Significance Index: 5.2700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.5425
    Cell Significance Index: 5.6200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.2460
    Cell Significance Index: 2.8600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0423
    Cell Significance Index: -0.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MIR200A is a 22-nucleotide long, single-stranded RNA that is highly conserved across species. It belongs to the microRNA family, which is characterized by its ability to bind to messenger RNA (mRNA) and regulate its expression. MIR200A is specifically expressed in various cell types, including neuronal receptor cells, smooth muscle myoblasts, lymphoid lineage restricted progenitor cells, pericytes, mast cells, endothelial cells, T cells, intestinal enteroendocrine cells, fibroblasts, and plasma cells. **Pathways and Functions:** MIR200A is involved in several signaling pathways that regulate cellular processes, including: 1. **Cellular response to amyloid-beta:** MIR200A has been shown to regulate the expression of genes involved in the cellular response to amyloid-beta, a protein that plays a central role in the pathogenesis of Alzheimer's disease. 2. **Mirna-mediated post-transcriptional gene silencing:** MIR200A uses its binding specificity to silence the expression of target genes, thereby regulating cellular processes such as cell migration, apoptosis, and immune response. 3. **Mrna base-pairing translational repressor activity:** MIR200A can also regulate gene expression by binding to specific mRNA sequences and preventing translation. 4. **Positive regulation of blood vessel endothelial cell migration:** MIR200A has been shown to promote the migration of endothelial cells, which is essential for angiogenesis and wound healing. 5. **Positive regulation of neuron apoptotic process:** MIR200A can also regulate the expression of genes involved in neuronal apoptosis, which is a critical process for eliminating damaged or dying neurons. **Clinical Significance:** Dysregulation of MIR200A has been implicated in various diseases, including: 1. **Alzheimer's disease:** MIR200A has been shown to regulate the expression of genes involved in the cellular response to amyloid-beta, and its dysregulation may contribute to the pathogenesis of Alzheimer's disease. 2. **Cancer:** MIR200A has been shown to regulate the expression of genes involved in cell migration, invasion, and metastasis, and its dysregulation may contribute to the development and progression of cancer. 3. **Inflammatory diseases:** MIR200A has been shown to regulate the expression of genes involved in immune response, and its dysregulation may contribute to the development of inflammatory diseases, such as rheumatoid arthritis and atherosclerosis. In conclusion, MIR200A is a critical regulator of cellular processes, including cell migration, apoptosis, and immune response. Its dysregulation has been implicated in various diseases, and further research is needed to fully understand its role in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.