Details for: RBMY1HP

Gene ID: 5944

Symbol: RBMY1HP

Ensembl ID: ENSG00000169811

Description: RNA binding motif protein Y-linked family 1 member H, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** RBMY1HP is located on the Y chromosome, which is unusual for a gene, as most genes are located on autosomes. Its expression is restricted to specific cell types, including retinal rod cells, CD1c-positive myeloid dendritic cells, and retinal cone cells. 2. **Pseudogene Status:** Despite its expression, RBMY1HP is classified as a pseudogene, meaning it lacks functional coding potential. 3. **Cellular Specificity:** The expression of RBMY1HP in specific cell types suggests a specialized role in immune cell regulation and retinal function. **Pathways and Functions:** 1. **Immune Cell Regulation:** The expression of RBMY1HP in CD1c-positive myeloid dendritic cells suggests a potential role in immune cell regulation, particularly in the context of antigen presentation and T-cell activation. 2. **Retinal Function:** The presence of RBMY1HP in retinal rod and cone cells implies a possible involvement in retinal function, possibly related to photoreceptor development, maintenance, or synaptic transmission. 3. **RNA Binding Motif:** The presence of an RNA binding motif (RBM) in RBMY1HP suggests a potential role in RNA processing, splicing, or degradation, which could have implications for gene expression and cellular function. **Clinical Significance:** 1. **Retinal Diseases:** The expression of RBMY1HP in retinal cells raises questions about its potential role in retinal diseases, such as retinitis pigmentosa or age-related macular degeneration. 2. **Immunological Disorders:** The presence of RBMY1HP in immune cells suggests a potential link to immunological disorders, such as autoimmune diseases or cancer. 3. **Gene Therapy:** Further investigation into the function of RBMY1HP could lead to the development of novel gene therapies targeting retinal or immune-related diseases. In conclusion, the RBMY1HP gene is a fascinating example of the complex interplay between gene expression and cellular function. Further research is necessary to fully understand its role in immune cell regulation and retinal function, as well as its potential implications for human disease. The discovery of RBMY1HP highlights the importance of considering the full spectrum of gene expression and its potential impact on human health.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.