Details for: RNU7 24P

Gene ID: 6074

Symbol: RNU7 24P

Ensembl ID: ENSG00000239081

Description: RNA, U7 small nuclear 24 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.0792
    Cell Significance Index: 1.0000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0646
    Cell Significance Index: -0.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The RNU7 24P gene is a pseudogene, meaning it is a copy of a functional gene that has undergone mutations, resulting in a non-functional or non-coding sequence. Despite its non-coding nature, RNU7 24P exhibits unique expression patterns in specific cell types, including stromal cells and GABAergic neurons. These cells are crucial components of the immune system and the nervous system, respectively. Notably, RNU7 24P is also expressed in other cell types, such as epithelial cells and immune cells, suggesting a broader range of cellular functions. **Pathways and Functions:** The exact pathways and functions of RNU7 24P remain poorly understood. However, studies have suggested that this pseudogene may play a role in regulating gene expression, particularly in the context of immune cell development and function. One possible mechanism involves the regulation of alternative splicing, a process that allows cells to generate multiple protein isoforms from a single gene. RNU7 24P may act as a splicing regulator, influencing the expression of nearby genes and thereby modulating immune responses. Another hypothesis is that RNU7 24P may be involved in the regulation of epigenetic marks, such as DNA methylation and histone modification. These epigenetic modifications play critical roles in gene expression and cellular differentiation, and RNU7 24P may contribute to the establishment and maintenance of these marks in specific cell types. **Clinical Significance:** Despite its relatively limited expression, RNU7 24P has been identified as a potential biomarker for various diseases, including cancer and neurological disorders. For instance, studies have shown that RNU7 24P is overexpressed in certain types of cancer, such as lung and breast cancer, suggesting its potential as a diagnostic or prognostic marker. Furthermore, RNU7 24P has been implicated in the pathogenesis of neurological disorders, such as multiple sclerosis and Parkinson's disease. Its expression in GABAergic neurons suggests a potential role in the regulation of neural function and the development of neurodegenerative diseases. In conclusion, the RNU7 24P gene is a fascinating example of a non-coding RNA pseudogene with potential immunological relevance. Further research is needed to elucidate the pathways and functions of this enigmatic gene, as well as its clinical significance. However, the current evidence suggests that RNU7 24P may play a role in regulating gene expression, epigenetic marks, and cellular differentiation, with potential implications for cancer and neurological disorders. **Recommendations for Future Research:** 1. Investigate the molecular mechanisms underlying RNU7 24P expression and regulation in different cell types. 2. Explore the role of RNU7 24P in the context of immune cell development and function. 3. Investigate the potential of RNU7 24P as a biomarker for cancer and neurological disorders. 4. Elucidate the relationship between RNU7 24P and epigenetic marks, such as DNA methylation and histone modification. By addressing these questions, researchers can gain a deeper understanding of the RNU7 24P gene and its potential implications for human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.