Details for: RRM2P4

Gene ID: 6246

Symbol: RRM2P4

Ensembl ID: ENSG00000235598

Description: ribonucleotide reductase M2 polypeptide pseudogene 4

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0001
    Cell Significance Index: 0.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0011
    Cell Significance Index: -0.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RRM2P4 is a pseudogene, meaning it has undergone extensive gene conversion, leading to the loss of its functional gene. As a result, this gene does not encode a protein that can be translated into a functional protein. Despite its pseudogene status, RRM2P4 is significantly expressed in specific neuronal populations, suggesting that it may play a role in regulating gene expression, particularly in the context of neuronal development and function. **Pathways and Functions:** The primary function of RRM2P4 is unclear, but its expression in specific neuronal populations suggests that it may be involved in regulating gene expression, particularly in the context of neural development and function. Ribonucleotide reductase, the enzyme encoded by the RRM2 gene, plays a crucial role in the synthesis of deoxyribonucleotides, which are essential for DNA replication and repair. The pseudogene RRM2P4 may be involved in regulating the expression of genes involved in these processes, potentially influencing neuronal development, differentiation, and function. **Clinical Significance:** The discovery of RRM2P4 expression in specific neuronal populations raises several questions about its clinical significance. As a pseudogene, RRM2P4 may not be directly involved in disease, but its expression in specific neuronal populations suggests that it may play a role in regulating gene expression, potentially influencing neurological disorders. Further research is needed to elucidate the functional significance of RRM2P4 and its potential involvement in neurological diseases. In conclusion, the RRM2P4 gene is a pseudogene with significant expression in specific neuronal populations, raising questions about its functional significance and potential involvement in neurological disorders. Further research is needed to elucidate the role of RRM2P4 in regulating gene expression and its potential implications for human health. **Potential Implications:** - Pseudogenes like RRM2P4 may play a role in regulating gene expression in specific neuronal populations, potentially influencing neurological disorders. - The expression of RRM2P4 in specific neuronal populations suggests that pseudogenes may be involved in regulating gene expression in the context of neural development and function. - Further research is needed to elucidate the functional significance of RRM2P4 and its potential involvement in neurological diseases. **Future Directions:** - Investigate the functional significance of RRM2P4 in regulating gene expression in specific neuronal populations. - Explore the potential involvement of RRM2P4 in neurological disorders, including neurodevelopmental and neurodegenerative diseases. - Investigate the mechanisms by which RRM2P4 regulates gene expression, including its potential interactions with other genes and regulatory elements.

Database document:

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