Details for: ZNF29P

Gene ID: 7577

Symbol: ZNF29P

Ensembl ID: ENSG00000108452

Description: zinc finger protein 29, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2364
    Cell Significance Index: 3.4900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1924
    Cell Significance Index: -2.4300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2319
    Cell Significance Index: -2.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc finger protein family:** ZNF29P belongs to the zinc finger protein family, a group of transcription factors that play crucial roles in regulating gene expression. These proteins typically possess a zinc finger motif that allows them to bind to specific DNA sequences, thereby influencing gene transcription. 2. **Pseudogene status:** Despite its expression in various tissues, ZNF29P has been identified as a pseudogene, indicating that it is a non-functional copy of a gene. This suggests that the gene has undergone processes of degeneration or mutation, leading to its loss of function. 3. **Significant expression in cardiac muscle cells, GABAergic neurons, and glutamatergic neurons:** ZNF29P has been found to be significantly expressed in these cells, suggesting that it may play a role in regulating their function. This is particularly interesting given the potential involvement of ZNF29P in the regulation of neuronal and cardiac functions. **Pathways and Functions:** 1. **Regulation of gene expression:** As a zinc finger protein, ZNF29P is likely involved in regulating gene expression by binding to specific DNA sequences and influencing transcription. Its expression in cardiac muscle cells and neurons suggests that it may play a role in regulating the expression of genes involved in these tissues. 2. **Neuronal function:** ZNF29P's expression in GABAergic and glutamatergic neurons suggests that it may be involved in regulating neuronal function, including synaptic plasticity and neurotransmitter release. Further research is needed to elucidate the specific mechanisms by which ZNF29P regulates neuronal function. 3. **Cardiac function:** The expression of ZNF29P in cardiac muscle cells suggests that it may play a role in regulating cardiac function, including contraction and relaxation. Further research is needed to determine the specific mechanisms by which ZNF29P regulates cardiac function. **Clinical Significance:** 1. **Neurological disorders:** ZNF29P's expression in GABAergic and glutamatergic neurons suggests that it may play a role in the regulation of neuronal function, which is critical in the development and progression of neurological disorders, such as epilepsy, Alzheimer's disease, and Parkinson's disease. 2. **Cardiac disease:** The expression of ZNF29P in cardiac muscle cells suggests that it may play a role in regulating cardiac function, which is critical in the development and progression of cardiac disease, such as heart failure and arrhythmias. 3. **Potential therapeutic targets:** Further research is needed to determine the specific mechanisms by which ZNF29P regulates neuronal and cardiac function, which may lead to the identification of potential therapeutic targets for the treatment of neurological and cardiac disorders. In conclusion, the ZNF29P pseudogene has sparked curiosity among researchers due to its unique expression patterns and potential involvement in the regulation of neuronal and cardiac functions. Further research is needed to elucidate the specific mechanisms by which ZNF29P regulates gene expression, neuronal function, and cardiac function, which may lead to the identification of potential therapeutic targets for the treatment of neurological and cardiac disorders.

Database document:

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