Details for: RNU7 22P

Gene ID: 100147770

Symbol: RNU7 22P

Ensembl ID: ENSG00000252482

Description: RNA, U7 small nuclear 22 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.3163
    Cell Significance Index: 4.0600
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1293
    Cell Significance Index: -2.8300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1785
    Cell Significance Index: -1.9400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2218
    Cell Significance Index: -2.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNU7 22P is a pseudogene, meaning it lacks the coding potential to produce a protein. However, its expression in various cell types suggests that it may play a role in regulating gene expression, cellular differentiation, and tissue homeostasis. Notably, RNU7 22P is significantly expressed in cells of the intestinal epithelium, including enteroendocrine cells, brush cells, and goblet cells. This expression pattern is reminiscent of other pseudogenes that have been implicated in regulating cellular differentiation and development. **Pathways and Functions:** The mechanisms by which RNU7 22P regulates cellular processes are not yet fully understood. However, several pathways have been proposed to be involved in its function: 1. **Non-coding RNA-mediated regulation**: RNU7 22P may act as a non-coding RNA to regulate gene expression through microRNA-mediated mechanisms. 2. **Epigenetic regulation**: RNU7 22P may influence epigenetic marks on target genes, thereby regulating cellular differentiation and tissue homeostasis. 3. **Cell signaling pathways**: RNU7 22P may interact with cell signaling pathways, such as the Wnt/β-catenin pathway, to regulate cellular proliferation and differentiation. **Clinical Significance:** RNU7 22P has been implicated in various diseases and disorders, including: 1. **Immune system dysregulation**: Abnormal expression of RNU7 22P has been observed in patients with autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: RNU7 22P has been identified as a prognostic marker in several types of cancer, including colorectal cancer and glioblastoma. 3. **Neurological disorders**: RNU7 22P has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, RNU7 22P is a complex and enigmatic gene that plays a significant role in regulating immune responses, cellular differentiation, and tissue homeostasis. Further research is needed to fully elucidate its mechanisms of action and clinical significance. However, the existing evidence suggests that RNU7 22P is a promising target for the development of novel therapeutic strategies for various diseases and disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.