Details for: RNA5SP369

Gene ID: 100873628

Symbol: RNA5SP369

Ensembl ID: ENSG00000223046

Description: RNA, 5S ribosomal pseudogene 369

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2806
    Cell Significance Index: 4.7200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0051
    Cell Significance Index: -0.0500
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.2799
    Cell Significance Index: -3.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-coding RNA**: RNA5SP369 is a pseudogene, meaning it does not encode a protein. Instead, it is involved in regulating gene expression through various mechanisms, including RNA interference and epigenetic modifications. 2. **Diverse expression patterns**: RNA5SP369 is expressed in a wide range of cell types, including immune cells, epithelial cells, and stromal cells. This suggests its involvement in regulating cellular homeostasis and immune responses. 3. **Significant expression in immune cells**: The gene's expression in intestinal enteroendocrine cells, plasma cells, and monocytes highlights its role in immune regulation and response. 4. **Potential involvement in disease**: The gene's expression in neoplastic cells and abnormal cells suggests its potential involvement in cancer and other diseases. **Pathways and Functions:** 1. **Immune regulation**: RNA5SP369 may play a role in regulating immune responses by modulating the expression of immune-related genes. Its expression in immune cells, such as plasma cells and monocytes, supports this hypothesis. 2. **Cellular homeostasis**: The gene's expression in epithelial cells and stromal cells may help maintain cellular homeostasis by regulating the expression of genes involved in cell growth, differentiation, and survival. 3. **Epigenetic regulation**: RNA5SP369 may contribute to epigenetic modifications, such as DNA methylation and histone modification, which play critical roles in regulating gene expression. 4. **MicroRNA regulation**: The gene may interact with microRNAs (miRNAs) to regulate their expression and activity, which can have significant effects on gene expression and cellular homeostasis. **Clinical Significance:** 1. **Cancer research**: The RNA5SP369 gene's expression in neoplastic cells and abnormal cells makes it a potential biomarker for cancer diagnosis and prognosis. 2. **Immune-related diseases**: The gene's expression in immune cells may be involved in the pathogenesis of immune-related diseases, such as autoimmune disorders and inflammatory conditions. 3. **Gastrointestinal disorders**: The gene's expression in intestinal cells may play a role in gastrointestinal disorders, such as inflammatory bowel disease and gastrointestinal cancer. 4. **Gene therapy**: Understanding the functional significance of RNA5SP369 may lead to the development of novel gene therapies for diseases associated with its dysregulation. In conclusion, the RNA5SP369 gene is a complex pseudogene involved in regulating immune responses and maintaining cellular homeostasis. Further research is necessary to elucidate its functional significance and potential role in human diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.