Details for: RNA5SP451

Gene ID: 100873696

Symbol: RNA5SP451

Ensembl ID: ENSG00000222520

Description: RNA, 5S ribosomal pseudogene 451

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.0067
    Cell Significance Index: 0.0600
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.0037
    Cell Significance Index: 0.0400
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0016
    Cell Significance Index: -0.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-coding nature**: RNA5SP451 is a pseudogene, meaning it does not encode a protein. Instead, it is a regulatory element that may influence gene expression or mRNA stability. 2. **High expression levels**: RNA5SP451 is significantly expressed in various cell types, indicating its potential role in regulating cellular processes. 3. **Intestinal tissue specificity**: The gene is predominantly expressed in intestinal tissues, suggesting a specific function in the gut-related immune system. 4. **Cell type specificity**: RNA5SP451 is expressed in a range of cell types, including enteroendocrine cells, plasma cells, brush cells, and stem cells, indicating a potential role in regulating cell differentiation, proliferation, or survival. **Pathways and Functions:** 1. **Immune regulation**: RNA5SP451 may play a role in regulating immune responses, particularly in the context of the intestinal microbiome. Its expression in plasma cells and other immune-related cells suggests a potential function in modulating antibody production or immune cell activation. 2. **Cell differentiation and proliferation**: The expression of RNA5SP451 in stem cells and other cell types may influence cell differentiation, proliferation, or survival, potentially contributing to tissue homeostasis and repair. 3. **RNA stability and processing**: As a pseudogene, RNA5SP451 may influence RNA stability or processing, thereby regulating the expression of nearby genes or influencing the overall transcriptome. **Clinical Significance:** 1. **Gastrointestinal disorders**: The expression of RNA5SP451 in intestinal tissues suggests a potential link to gastrointestinal disorders, such as inflammatory bowel disease (IBD), celiac disease, or cancer. 2. **Immune-related diseases**: The gene's expression in plasma cells and other immune-related cells may contribute to the pathogenesis of immune-related diseases, such as rheumatoid arthritis or multiple sclerosis. 3. **Cancer research**: RNA5SP451's expression in neoplastic and stem cells may be relevant to cancer research, particularly in the context of intestinal cancer or leukemia. In conclusion, the RNA5SP451 gene is a pseudogene with widespread expression in intestinal tissues and potential implications for immune function and disease. Further research is needed to fully understand the gene's function and its role in regulating cellular processes.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.