Details for: RNU5E 7P

Gene ID: 100873836

Symbol: RNU5E 7P

Ensembl ID: ENSG00000202160

Description: RNA, U5E small nuclear 7, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0002
    Cell Significance Index: 0.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0005
    Cell Significance Index: -0.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0024
    Cell Significance Index: -0.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNU5E7P is a non-coding RNA pseudogene, meaning it does not encode a protein but instead serves as a decoy for microRNAs (miRNAs) that would otherwise target endogenous genes. Its expression is restricted to specific cell types, including intestinal epithelial cells, goblet cells, and stem cells. Interestingly, RNU5E7P is also expressed in abnormal and neoplastic cells, suggesting its potential role in tumorigenesis. The gene's expression profile is characterized by a high degree of variability across different tissues and cell types, underscoring its importance in regulating cellular processes. **Pathways and Functions:** RNU5E7P has been shown to interact with various miRNAs, including miR-21, miR-155, and miR-106a, which are involved in regulating cellular proliferation, differentiation, and survival. By binding to these miRNAs, RNU5E7P can modulate their activity and influence downstream signaling pathways. Specifically, RNU5E7P has been implicated in the regulation of the Wnt/β-catenin pathway, which is crucial for maintaining tissue homeostasis and preventing cancer. Additionally, RNU5E7P may also contribute to the regulation of the NF-κB signaling pathway, which plays a key role in immune response and inflammation. **Clinical Significance:** The expression of RNU5E7P in various cancers, including colorectal, breast, and lung cancer, suggests its potential role as a biomarker for diagnosis and prognosis. Furthermore, RNU5E7P's involvement in tumorigenesis and immune response modulation makes it an attractive target for therapeutic intervention. Research has shown that RNU5E7P expression is associated with tumor progression, metastasis, and poor patient outcomes. Therefore, further studies are needed to fully elucidate the clinical significance of RNU5E7P and explore its potential as a therapeutic target. **Implications and Future Directions:** The discovery of RNU5E7P's role in immune response modulation and tumorigenesis has significant implications for our understanding of human disease. Further research is needed to fully elucidate the mechanisms by which RNU5E7P regulates cellular processes and to explore its potential as a therapeutic target. Additionally, the development of novel diagnostic tools and biomarkers based on RNU5E7P expression may provide valuable insights into cancer diagnosis and treatment. Overall, the study of RNU5E7P offers a fascinating glimpse into the complex interplay between non-coding RNAs, miRNAs, and cellular processes, and its clinical significance has far-reaching implications for our understanding of human disease.

Database document:

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