Details for: RNU7 167P

Gene ID: 106479088

Symbol: RNU7 167P

Ensembl ID: ENSG00000238584

Description: RNA, U7 small nuclear 167 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0766
    Cell Significance Index: 0.9100
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.0702
    Cell Significance Index: 0.9300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0901
    Cell Significance Index: -0.9700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0916
    Cell Significance Index: -1.0000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0946
    Cell Significance Index: -1.1300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1352
    Cell Significance Index: -1.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-coding nature:** RNU7 167P is a pseudogene, which means it lacks the ability to produce a functional protein. Despite this, it is transcribed and processed similarly to its canonical counterpart, U7 small nuclear RNA (snRNA). 2. **Widespread expression:** RNU7 167P is significantly expressed in various cell types within the intestinal epithelium, including intestinal enteroendocrine cells, brush cells, intestinal epithelial cells, goblet cells, and stem cells. 3. **Cellular localization:** Its expression is confined to the intestinal epithelium, suggesting a specific role in maintaining intestinal homeostasis. **Pathways and Functions:** While the exact mechanisms of RNU7 167P are still unclear, several pathways and processes are thought to be involved: 1. **MicroRNA regulation:** RNU7 167P may play a role in regulating microRNA (miRNA) expression, which is crucial for controlling gene expression and cellular processes. 2. **Epigenetic regulation:** This pseudogene may influence epigenetic marks, such as DNA methylation and histone modification, which are essential for maintaining cellular identity and function. 3. **Cellular differentiation:** RNU7 167P may contribute to the regulation of cellular differentiation, particularly in the context of intestinal epithelial cells. 4. **Stem cell maintenance:** Its expression in intestinal crypt stem cells suggests a potential role in maintaining the integrity of the intestinal stem cell niche. **Clinical Significance:** RNU7 167P's involvement in intestinal homeostasis and disease progression warrants further investigation. Some potential clinical implications include: 1. **Intestinal cancer:** Aberrant expression of RNU7 167P has been observed in various types of intestinal cancer, suggesting a potential role in tumorigenesis. 2. **Inflammatory bowel disease (IBD):** Its expression profile may be altered in IBD patients, potentially contributing to disease pathogenesis. 3. **Gastrointestinal disorders:** RNU7 167P may play a role in regulating cellular processes that contribute to gastrointestinal disorders, such as irritable bowel syndrome (IBS) and Crohn's disease. In conclusion, while the functional significance of RNU7 167P remains unclear, its widespread expression and potential involvement in regulating cellular processes make it an intriguing target for further investigation. As our understanding of this pseudogene evolves, it is likely to shed light on the complex mechanisms underlying intestinal homeostasis and disease progression.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.