Details for: RN7SL722P

Gene ID: 106479486

Symbol: RN7SL722P

Ensembl ID: ENSG00000273940

Description: RNA, 7SL, cytoplasmic 722, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0074
    Cell Significance Index: -0.0700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0106
    Cell Significance Index: -0.1300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0112
    Cell Significance Index: -0.1000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0129
    Cell Significance Index: -0.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RN7SL722P exhibits several key characteristics that are worth noting: 1. **Pseudogene**: As mentioned earlier, RN7SL722P lacks the ability to encode a protein, making it a pseudogene. 2. **Widespread expression**: The gene is significantly expressed in various cell types of the intestine, including enteroendocrine cells, brush cells, and intestinal epithelial cells. 3. **Intestinal specificity**: RN7SL722P is primarily expressed in the intestine, with minimal or no expression in other tissues. 4. **Cell-type specificity**: The gene exhibits cell-type specificity, with distinct expression patterns in different cell types within the intestine. **Pathways and Functions** The exact pathways and functions of RN7SL722P are not yet fully understood. However, based on its expression patterns and cellular localization, several hypotheses can be proposed: 1. **Regulation of cell proliferation and differentiation**: RN7SL722P may play a role in regulating cell proliferation and differentiation in the intestinal epithelium, particularly in stem cells and transit amplifying cells. 2. **Maintenance of intestinal homeostasis**: The gene may contribute to maintaining intestinal homeostasis by regulating the function of various cell types, including enteroendocrine cells and goblet cells. 3. **Inflammation and immune response**: RN7SL722P may also be involved in the regulation of inflammation and immune response in the intestine, particularly in response to microbial colonization and pathogen invasion. 4. **Cancer development**: The gene's expression in neoplastic cells suggests that RN7SL722P may be involved in the development and progression of colorectal cancer. **Clinical Significance** RN7SL722P has significant clinical implications, particularly in the context of intestinal diseases and cancer: 1. **Colorectal cancer**: The gene's expression in neoplastic cells highlights its potential role in the development and progression of colorectal cancer. 2. **Inflammatory bowel disease**: RN7SL722P may also be involved in the regulation of inflammation and immune response in inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis. 3. **Intestinal homeostasis**: The gene's expression in intestinal epithelial cells and goblet cells suggests that RN7SL722P may play a role in maintaining intestinal homeostasis and preventing disease. 4. **Diagnostic and therapeutic applications**: Further research is needed to determine the potential diagnostic and therapeutic applications of RN7SL722P in intestinal diseases and cancer. In conclusion, RN7SL722P is a pseudogene with significant expression in various cell types of the intestine, highlighting its potential roles in intestinal homeostasis, cell proliferation and differentiation, and inflammation and immune response. Further research is needed to fully understand the functions and clinical significance of this gene.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.