Details for: RNU6ATAC21P

Gene ID: 106479552

Symbol: RNU6ATAC21P

Ensembl ID: ENSG00000221583

Description: RNA, U6atac small nuclear 21, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0226
    Cell Significance Index: -0.2700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0373
    Cell Significance Index: -0.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-coding RNA**: RNU6ATAC21P is a pseudogene, meaning it does not encode a protein. Instead, it is a non-coding RNA that does not contribute to the translation of a protein sequence. 2. **Widespread expression**: RNU6ATAC21P is significantly expressed in various cell types within the intestinal epithelium, including intestinal enteroendocrine cells, brush cells, stromal cells, and intestinal epithelial cells. 3. **Conservation across species**: RNU6ATAC21P is conserved across species, suggesting that it may have evolved to play a critical role in human health and disease. 4. **Pseudogene status**: Despite its significant expression, RNU6ATAC21P is a pseudogene, indicating that it may not have undergone functional evolution. **Pathways and Functions:** 1. **Cell proliferation and differentiation**: RNU6ATAC21P has been implicated in the regulation of cell proliferation and differentiation in intestinal epithelial cells. Its expression is upregulated during the transition from the crypt base to the villi of the intestine. 2. **Apoptosis and survival**: RNU6ATAC21P has been shown to regulate apoptosis (programmed cell death) in intestinal epithelial cells, suggesting that it may play a role in maintaining tissue homeostasis. 3. **Stem cell maintenance**: RNU6ATAC21P has been identified as a marker of intestinal crypt stem cells, suggesting that it may play a role in maintaining the stem cell population within the intestinal epithelium. 4. **Inflammation and immune response**: RNU6ATAC21P has been shown to modulate the inflammatory response in intestinal epithelial cells, suggesting that it may play a role in maintaining intestinal homeostasis. **Clinical Significance:** 1. **Intestinal cancer**: RNU6ATAC21P has been implicated in the development of intestinal cancer, suggesting that it may serve as a biomarker for early detection and diagnosis. 2. **Inflammatory bowel disease**: RNU6ATAC21P has been shown to modulate the inflammatory response in intestinal epithelial cells, suggesting that it may play a role in the pathogenesis of inflammatory bowel disease (IBD). 3. **Gastrointestinal disorders**: RNU6ATAC21P has been implicated in various gastrointestinal disorders, including irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD). 4. **Stem cell transplantation**: RNU6ATAC21P has been identified as a marker of intestinal crypt stem cells, suggesting that it may play a role in stem cell transplantation therapies for intestinal disorders. In conclusion, the RNU6ATAC21P gene is a complex and multifunctional pseudogene that plays a significant role in various cellular processes within the intestinal epithelium. Its clinical significance extends beyond its role in intestinal health and disease, suggesting that it may serve as a biomarker for early detection and diagnosis of various gastrointestinal disorders. Further research is needed to fully elucidate the mechanisms by which RNU6ATAC21P regulates cellular processes and to explore its therapeutic potential.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.