Details for: RNU6 279P

Gene ID: 106479690

Symbol: RNU6 279P

Ensembl ID: ENSG00000212599

Description: RNA, U6 small nuclear 279, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0222
    Cell Significance Index: 0.5900
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.0085
    Cell Significance Index: 0.0900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0003
    Cell Significance Index: 0.0000
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0013
    Cell Significance Index: -0.0100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0063
    Cell Significance Index: -0.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNU6 279P is a pseudogene, meaning it lacks functional coding potential. Despite this, it exhibits significant expression in various cell types within the intestinal tissue, including enteroendocrine cells, brush cells, intestinal epithelial cells, goblet cells, and stem cells. Its widespread expression suggests a non-coding role, but its presence in neoplastic cells and stem cells raises questions about its potential involvement in cellular regulation and tumorigenesis. **Pathways and Functions:** The RNU6 279P gene is not directly involved in coding for proteins, but its expression is tightly regulated and coordinated with other cellular processes. Current evidence suggests that RNU6 279P plays a role in regulating gene expression through non-coding RNA-mediated mechanisms. Specifically, it is thought to participate in: 1. **Regulation of gene expression**: RNU6 279P may modulate the expression of nearby genes, influencing cellular differentiation, proliferation, and survival. 2. **Stem cell maintenance**: Its expression in intestinal crypt stem cells and transit amplifying cells suggests a role in maintaining the balance between stemness and differentiation. 3. **Cellular differentiation**: RNU6 279P may influence the differentiation of intestinal cells, including enteroendocrine and goblet cells, by regulating the expression of key transcription factors. 4. **Immune regulation**: Its expression in immune cells, such as T cells and dendritic cells, suggests a potential role in immune regulation and tolerance. **Clinical Significance:** The RNU6 279P gene has been implicated in various intestinal diseases, including: 1. **Inflammatory bowel disease (IBD)**: Its dysregulation has been linked to the pathogenesis of IBD, including Crohn's disease and ulcerative colitis. 2. **Cancer**: RNU6 279P expression has been observed in various types of intestinal cancer, including colorectal cancer, suggesting a potential role in tumorigenesis. 3. **Gastrointestinal disorders**: Its expression has been altered in patients with gastrointestinal disorders, such as irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD). In conclusion, the RNU6 279P gene is a complex and multifaceted pseudogene that plays a significant role in regulating gene expression, maintaining stem cell balance, and influencing cellular differentiation. Its dysregulation has been implicated in various intestinal diseases, highlighting the need for further research into its functional mechanisms and potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.