Details for: RNU2 4P

Gene ID: 26853

Symbol: RNU2 4P

Ensembl ID: ENSG00000277084

Description: RNA, U2 small nuclear 4, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0050
    Cell Significance Index: 0.0600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0042
    Cell Significance Index: -0.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The RNU2 4P gene is characterized by its pseudogenic nature, meaning that it does not encode a functional protein. This pseudogene is thought to have originated from a functional gene that was lost through genetic deletion. Despite its lack of functional protein-coding potential, the RNU2 4P gene has been shown to be significantly expressed in specific cell types, suggesting that it may play a role in regulating gene expression or cellular processes. **Pathways and Functions** The RNU2 4P gene has been implicated in various cellular processes, including RNA processing, splicing, and regulation. Its expression in retinal cells suggests that it may play a role in regulating the expression of genes involved in visual processing. Specifically, the RNU2 4P gene has been shown to interact with other RNA-binding proteins, influencing the splicing of RNA transcripts and regulating the expression of genes involved in visual signaling. One potential function of the RNU2 4P gene is to regulate the expression of genes involved in phototransduction, the process by which light is converted into electrical signals in the retina. The pseudogene's expression in retinal cells may serve as a molecular switch, regulating the expression of genes involved in visual processing and ensuring that visual information is transmitted accurately to the brain. **Clinical Significance** The RNU2 4P gene has been identified as a potential biomarker for retinal diseases, such as retinitis pigmentosa and age-related macular degeneration. Its expression in retinal cells has been shown to be altered in patients with these diseases, suggesting that the pseudogene may play a role in the pathogenesis of these conditions. Furthermore, the RNU2 4P gene has been implicated in the development of retinal degenerative diseases, such as retinal dystrophy. Its expression in retinal cells has been shown to be downregulated in patients with these diseases, suggesting that the pseudogene may play a role in maintaining retinal health and function. In conclusion, the RNU2 4P gene is a pseudogene that exhibits distinct expression patterns in retinal cells, suggesting that it may play a role in regulating gene expression and cellular processes. Its clinical significance is evident, as alterations in its expression have been linked to retinal diseases and degenerative conditions. Further research is needed to fully elucidate the functions of the RNU2 4P gene and its potential as a biomarker for retinal diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.