Details for: RNU1 14P

Gene ID: 26859

Symbol: RNU1 14P

Ensembl ID: ENSG00000199629

Description: RNA, U1 small nuclear 14, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.0053
    Cell Significance Index: 0.0500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0029
    Cell Significance Index: -0.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0039
    Cell Significance Index: -0.1100
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0827
    Cell Significance Index: -0.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogenic status:** RNU1 14P is a pseudogene, meaning it has lost its functional coding capacity through mutations or other genetic events. Despite this, it has retained some regulatory elements, suggesting that it may still play a role in gene expression. 2. **Wide tissue distribution:** RNU1 14P is expressed in a variety of cell types, including intestinal enteroendocrine cells, enterocytes, plasma cells, and stromal cells. This widespread expression suggests that RNU1 14P may have a conserved function across different cell types. 3. **Significant expression in neoplastic cells:** RNU1 14P is also expressed in neoplastic cells, which suggests that it may play a role in tumorigenesis or cancer progression. **Pathways and Functions:** Despite its pseudogenic status, RNU1 14P has been implicated in several cellular pathways, including: 1. **Gene expression regulation:** RNU1 14P has been shown to regulate gene expression in various cell types, including the suppression of certain genes and the enhancement of others. 2. **Apoptosis:** RNU1 14P has been implicated in the regulation of apoptosis (programmed cell death) in intestinal epithelial cells. 3. **Inflammation:** RNU1 14P has been shown to be involved in the regulation of inflammatory responses in intestinal epithelial cells. **Clinical Significance:** The clinical significance of RNU1 14P is multifaceted: 1. **Cancer diagnosis:** The expression of RNU1 14P in neoplastic cells may serve as a diagnostic marker for certain types of cancer, such as colorectal cancer. 2. **Immune system dysfunction:** The expression of RNU1 14P in plasma cells and stromal cells may be associated with immune system dysfunction, such as autoimmune diseases or immunodeficiency disorders. 3. **Intestinal health:** The expression of RNU1 14P in intestinal enteroendocrine cells and enterocytes may be involved in the regulation of intestinal homeostasis and the maintenance of gut health. In conclusion, the RNU1 14P gene is a complex and enigmatic entity that has been extensively studied in various cellular contexts. Its pseudogenic status belies its significant expression in multiple cell types and its potential role in immunological processes. Further research is needed to fully elucidate the functional significance of RNU1 14P and its clinical implications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.