Details for: IGHD3 22

Gene ID: 28497

Symbol: IGHD3 22

Ensembl ID: ENSG00000211911

Description: immunoglobulin heavy diversity 3-22

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: B cell (CL0000236)
    Fold Change: 0.09
    Marker Score: 90
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 16

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** IGHD3 is situated on chromosome 2 and is highly expressed in B cells, particularly in unswitched memory B cells, class-switched memory B cells, and plasma cells. 2. **Gene Structure:** The IGHD3 gene consists of a single exon and is characterized by a unique structure, which may contribute to its specific expression and function in B cells. 3. **Function:** IGHD3 is involved in the generation of immunoglobulin diversity, a process that is essential for the immune system's ability to recognize and respond to a wide range of antigens. **Pathways and Functions:** IGHD3's primary function is to contribute to the generation of immunoglobulin diversity through the following mechanisms: 1. **V(D)J Recombination:** IGHD3 participates in the V(D)J recombination process, which is a complex mechanism that generates diversity in the immunoglobulin heavy chain gene. This process involves the random recombination of V, D, and J gene segments to produce a unique immunoglobulin variable region. 2. **Immunoglobulin Heavy Chain Gene Rearrangement:** IGHD3 is involved in the rearrangement of the immunoglobulin heavy chain gene, which is a critical step in the development and maturation of B cells. 3. **B Cell Development and Maturation:** IGHD3 plays a role in the development and maturation of B cells, particularly in the transition from pro-B cells to mature B cells. **Clinical Significance:** IGHD3's role in immunoglobulin diversity and B cell function has significant implications for our understanding of immune function and disease. Dysregulation or mutations in the IGHD3 gene may contribute to various immunological disorders, including: 1. **Immunodeficiency Diseases:** Mutations in the IGHD3 gene may lead to impaired immunoglobulin diversity, resulting in impaired immune function and increased susceptibility to infections. 2. **Autoimmune Diseases:** Dysregulation of the IGHD3 gene may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus, by impairing the immune system's ability to recognize and respond to self-antigens. 3. **Cancer:** The IGHD3 gene's role in immunoglobulin diversity and B cell function may also be relevant to the development and progression of certain cancers, such as lymphoma and leukemia. In conclusion, IGHD3 is a gene of critical importance in B cell function and immunoglobulin diversity. Its unique structure and expression pattern in B cells suggest a specific role in the generation of immunoglobulin diversity. Further research is needed to fully elucidate the mechanisms by which IGHD3 contributes to immune function and to understand its clinical significance in the context of immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.