Details for: IGHD1 20

Gene ID: 28507

Symbol: IGHD1 20

Ensembl ID: ENSG00000237020

Description: immunoglobulin heavy diversity 1-20

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0332
    Cell Significance Index: 0.8400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0272
    Cell Significance Index: 0.4400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0378
    Cell Significance Index: -0.5000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0393
    Cell Significance Index: -0.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHD1-20 is a member of the immunoglobulin heavy chain gene family, which is responsible for encoding the variable region of the heavy chain of antibodies. This gene is characterized by its unique structure, which includes a diverse repertoire of variable (VH) and constant (CH) domains. The VH domain is responsible for recognizing and binding to specific antigens, while the CH domain determines the class and subclass of the antibody. IGHD1-20 is specifically expressed in cells that are involved in the production of antibodies, such as B cells and mast cells. **Pathways and Functions:** IGHD1-20 is involved in several key signaling pathways that regulate immune cell development, activation, and function. These pathways include: 1. **Notch signaling pathway**: IGHD1-20 interacts with Notch receptors, which are essential for the development and maturation of hematopoietic stem cells. 2. **Wnt/β-catenin signaling pathway**: IGHD1-20 regulates the Wnt/β-catenin pathway, which is involved in the maintenance of hematopoietic stem cell self-renewal and differentiation. 3. **NF-κB signaling pathway**: IGHD1-20 modulates the NF-κB pathway, which is crucial for the regulation of immune cell activation, proliferation, and survival. IGHD1-20 plays a crucial role in the development and function of various immune cells, including: 1. **B cells**: IGHD1-20 is essential for the development and maturation of B cells, which are responsible for producing antibodies. 2. **Mast cells**: IGHD1-20 regulates the function and development of mast cells, which are involved in the regulation of immune responses and allergic reactions. 3. **Hematopoietic stem cells**: IGHD1-20 is involved in the maintenance of hematopoietic stem cell self-renewal and differentiation. **Clinical Significance:** Dysregulation of IGHD1-20 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: Abnormal expression of IGHD1-20 has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: IGHD1-20 has been found to be overexpressed in certain types of cancer, including leukemia and lymphoma. 3. **Immunodeficiency disorders**: IGHD1-20 mutations have been identified in individuals with immunodeficiency disorders, such as X-linked agammaglobulinemia. In conclusion, IGHD1-20 is a critical gene that plays a vital role in the development and function of various immune cells. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of understanding its mechanisms and signaling pathways. Further research is needed to fully elucidate the role of IGHD1-20 in maintaining immune homeostasis and to explore its potential therapeutic applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.