Details for: IGLVV 58

Gene ID: 28758

Symbol: IGLVV 58

Ensembl ID: ENSG00000253637

Description: immunoglobulin lambda variable (V)-58 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 19

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGLVV58 is a pseudogene, meaning it lacks the functional coding regions necessary for producing a complete protein. Despite this, the gene is significantly expressed in macrophages, a type of immune cell crucial for phagocytosis and antigen presentation. IGLVV58 is also expressed in specific types of neurons, including L5 extratelencephalic projecting glutamatergic cortical neurons and L2/3-6 intratelencephalic projecting glutamatergic neurons. These neurons are involved in regulating various physiological processes, including synaptic plasticity and neuronal communication. **Pathways and Functions:** While the precise function of IGLVV58 remains unknown, its expression in macrophages suggests that it may play a role in modulating immune responses. One possible pathway involves IGLVV58 influencing the production of cytokines and chemokines, which are critical signaling molecules in the immune system. Additionally, IGLVV58 may interact with other genes involved in immune regulation, such as the JAK/STAT pathway, to fine-tune immune responses. In neurons, IGLVV58 may contribute to the development and maintenance of synaptic plasticity, a critical process underlying learning and memory. The expression of IGLVV58 in specific types of neurons may also influence neuronal communication, potentially modulating the release of neurotransmitters and neuromodulators. **Clinical Significance:** The clinical significance of IGLVV58 remains largely unexplored, as its pseudogenic nature limits its potential as a therapeutic target. However, further research on IGLVV58 may provide insights into the mechanisms underlying immune regulation and neuronal communication. For instance, understanding the role of IGLVV58 in macrophages may lead to the development of novel therapeutic strategies for immune-related disorders, such as autoimmune diseases or cancer. Furthermore, the expression of IGLVV58 in specific types of neurons raises intriguing questions about its potential role in neurological disorders. For example, alterations in IGLVV58 expression may contribute to the development of neurodegenerative diseases, such as Alzheimer's or Parkinson's disease. Elucidating the mechanisms underlying IGLVV58's role in neurons may ultimately lead to the identification of novel therapeutic targets for these devastating conditions. In conclusion, the immunoglobulin lambda variable (V)-58 (IGLVV58) pseudogene is a complex and enigmatic gene that warrants further investigation. While its precise function remains unknown, its expression in macrophages and specific types of neurons suggests that it may play a role in modulating immune responses and neuronal communication. Further research on IGLVV58 may provide valuable insights into the mechanisms underlying immune regulation and neurological disorders, ultimately leading to the development of novel therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.