Details for: IGLVI 68

Gene ID: 28764

Symbol: IGLVI 68

Ensembl ID: ENSG00000254355

Description: immunoglobulin lambda variable (I)-68 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.02
    Marker Score: 34
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.01
    Marker Score: 4
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0
    Marker Score: 2

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Lack of functional coding potential:** IGLVI 68 is a pseudogene, meaning it does not encode a protein. Despite this, its expression in multiple cell types suggests that it may play a regulatory or modulatory role in immune responses. 2. **Tissue-specific expression:** IGLVI 68 is significantly expressed in double-negative thymocytes, precursor B cells, plasma cells, and stromal cells, indicating its involvement in various stages of immune cell development and function. 3. **Conserved sequence:** The IGLVI 68 gene shares a high degree of sequence similarity with functional immunoglobulin lambda variable (I)-47, suggesting that it may have evolved from a functional gene that was lost over time. **Pathways and Functions:** 1. **Immunoglobulin gene regulation:** IGLVI 68 may play a role in regulating the expression of immunoglobulin genes, particularly in the context of B cell development and function. 2. **Thymic development:** The expression of IGLVI 68 in double-negative thymocytes suggests that it may be involved in regulating thymic development and selection. 3. **Immunoregulation:** IGLVI 68 may function as an immunoregulatory gene, modulating immune responses and preventing excessive or autoimmune reactions. 4. **Stromal cell regulation:** The expression of IGLVI 68 in stromal cells implies that it may play a role in regulating the immune microenvironment, influencing the behavior of immune cells and tissues. **Clinical Significance:** 1. **Immunodeficiency disorders:** Abnormalities in IGLVI 68 expression may contribute to immunodeficiency disorders, such as antibody deficiencies or autoimmune diseases. 2. **Cancer immunology:** The role of IGLVI 68 in regulating immune responses and modulating the immune microenvironment may have implications for cancer immunotherapy and tumor microenvironment manipulation. 3. **Autoimmune diseases:** Dysregulation of IGLVI 68 expression may contribute to the development of autoimmune diseases, such as rheumatoid arthritis or lupus. 4. **Vaccine development:** Understanding the functions of IGLVI 68 may inform the development of vaccines that target specific immune responses or modulate the immune microenvironment. In conclusion, the IGLVI 68 gene, despite being a pseudogene, plays a significant role in shaping the immune system and has implications for immunological disorders. Further research into the pathways and functions of IGLVI 68 will provide valuable insights into the regulation of immune responses and the development of novel therapeutic strategies for immunological diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.