Details for: IGLVI 63

Gene ID: 28765

Symbol: IGLVI 63

Ensembl ID: ENSG00000253752

Description: immunoglobulin lambda variable (I)-63 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: B cell (CL0000236)
    Fold Change: 0.09
    Marker Score: 86
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0
    Marker Score: 5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0
    Marker Score: 5

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status**: IGLVI-63 is classified as a pseudogene, meaning it lacks a functional coding sequence and is unable to produce a mature protein. 2. **Ubiquitous expression**: This gene is significantly expressed in B cells, plasma cells, and stromal cells, indicating its widespread involvement in immune and cellular processes. 3. **Variable expression levels**: The expression levels of IGLVI-63 have been reported to vary across different cell types and tissues, suggesting a dynamic role in regulating cellular processes. 4. **Consequence of gene expression**: The functional consequences of IGLVI-63 expression are not yet fully understood, but its presence may influence cellular behavior, differentiation, or survival. **Pathways and Functions:** The exact pathways and functions of IGLVI-63 are not yet fully elucidated. However, based on its expression patterns and potential regulatory roles, several hypotheses have been proposed: 1. **Regulation of B cell development and differentiation**: IGLVI-63 may play a role in regulating B cell development, differentiation, or survival, potentially influencing the immune response. 2. **Stromal cell function**: The expression of IGLVI-63 in stromal cells may contribute to their regulatory functions, including tissue repair, immune modulation, or cellular signaling. 3. **Cellular signaling and proliferation**: IGLVI-63 may be involved in regulating cellular signaling pathways, influencing cell proliferation, survival, or differentiation. 4. **Gene expression regulation**: The pseudogene may act as a regulator of gene expression, modulating the expression of other genes involved in immune responses or cellular processes. **Clinical Significance:** While the clinical significance of IGLVI-63 is not yet fully understood, its expression in various cell types and tissues suggests potential implications for: 1. **Immunological disorders**: Alterations in IGLVI-63 expression may be associated with immunological disorders, such as autoimmune diseases, cancer, or immune-mediated disorders. 2. **Cancer**: The expression of IGLVI-63 in cancer cells may contribute to tumor progression, metastasis, or immune evasion. 3. **Regenerative medicine**: The pseudogene's role in stromal cell function and tissue repair may have implications for regenerative medicine, particularly in the context of tissue engineering or organ transplantation. 4. **Gene therapy**: The development of gene therapy strategies targeting IGLVI-63 may provide insights into regulating gene expression and modulating cellular behavior. In conclusion, the Immunoglobulin Lambda Variable (I)-63 pseudogene is a complex gene with multiple potential roles in regulating immune responses, cellular processes, and tissue function. Further research is necessary to fully elucidate its characteristics, pathways, and functions, as well as its clinical significance and potential applications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.