Details for: IGKV2D 36

Gene ID: 28880

Symbol: IGKV2D 36

Ensembl ID: ENSG00000253127

Description: immunoglobulin kappa variable 2D-36 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.0003
    Cell Significance Index: 0.0000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV2D 36 exhibits several distinct features that set it apart from other IgK genes. Firstly, it is classified as a pseudogene, meaning that it has undergone significant degeneration and is no longer capable of encoding a functional protein. This is evident from its high degree of similarity to other pseudogenes within the IgK family. Furthermore, IGKV2D 36 is primarily expressed in plasmablasts, a subset of B cells that are committed to antibody production. This expression pattern is intriguing, as it suggests that IGKV2D 36 may have a specialized role in the terminal differentiation of plasmablasts. **Pathways and Functions:** While IGKV2D 36 is not functional, research has suggested that it may participate in alternative regulatory pathways. One possible function of IGKV2D 36 is to act as a transcriptional regulator, influencing the expression of other IgK genes or other immune-related genes. This would involve the interaction with other transcription factors or chromatin-modifying enzymes, potentially modulating the immune response to specific pathogens or tissues. Another hypothesis is that IGKV2D 36 may serve as a decoy or "sink" for regulatory proteins, thereby preventing their interaction with functional IgK genes and maintaining the balance of the immune system. **Clinical Significance:** The clinical significance of IGKV2D 36 is still largely unknown, as its expression is limited to plasmablasts and its functional status is unclear. However, research into this gene may provide insights into the regulation of the immune response, particularly in the context of antibody production and B cell differentiation. Furthermore, IGKV2D 36 may serve as a potential biomarker for certain diseases, such as autoimmune disorders or lymphoproliferative disorders, where dysregulation of B cell function is implicated. In conclusion, IGKV2D 36 is a fascinating example of the complex and dynamic nature of the human immune system. While its functional status is still unclear, research into this gene has the potential to reveal new insights into the regulation of the immune response and the development of novel therapeutic strategies for immune-related diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.