Details for: MIR183

Gene ID: 406959

Symbol: MIR183

Ensembl ID: ENSG00000207691

Description: microRNA 183

Associated with

  • Extracellular space
    (GO:0005615)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna 3'-utr binding
    (GO:0003730)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of cell-substrate adhesion
    (GO:0010812)
  • Negative regulation of gene expression
    (GO:0010629)
  • Positive regulation of canonical wnt signaling pathway
    (GO:0090263)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of phagocytosis
    (GO:0050766)
  • Risc complex
    (GO:0016442)
  • Transforming growth factor beta receptor signaling pathway
    (GO:0007179)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0117
    Cell Significance Index: 0.1400
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0080
    Cell Significance Index: -0.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell-type specific expression**: MIR183 is expressed in a wide range of cell types, including neuronal receptor cells, smooth muscle myoblasts, and intestinal epithelial cells. 2. **Regulatory mechanisms**: MIR183 exhibits both positive and negative regulatory functions, influencing cell adhesion, gene expression, and signaling pathways. 3. **Target recognition**: MIR183 binds to the 3'-untranslated region (UTR) of target mRNAs, modulating their translation and stability. 4. **Signaling pathway modulation**: MIR183 regulates the canonical Wnt signaling pathway, phagocytosis, and transforming growth factor-beta receptor signaling. **Pathways and Functions:** 1. **Extracellular space regulation**: MIR183 influences cell-substrate adhesion, modulating the interaction between cells and their environment. 2. **Gene expression regulation**: MIR183 targets mRNAs involved in various cellular processes, including cell proliferation, differentiation, and survival. 3. **Signaling pathway modulation**: MIR183 regulates key signaling pathways, including the canonical Wnt signaling pathway, phagocytosis, and transforming growth factor-beta receptor signaling. 4. **Immune response regulation**: MIR183 has been implicated in the regulation of immune responses, including phagocytosis and the activation of immune cells. **Clinical Significance:** Dysregulation of MIR183 has been associated with various diseases, including: 1. **Cancer**: MIR183 has been implicated in the regulation of cancer cell growth, invasion, and metastasis. 2. **Neurological disorders**: MIR183 has been linked to neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Inflammatory diseases**: MIR183 has been implicated in the regulation of inflammatory responses, including arthritis and asthma. 4. **Gastrointestinal disorders**: MIR183 has been associated with gastrointestinal disorders, including inflammatory bowel disease and colon cancer. In conclusion, MIR183 is a complex gene with multiple regulatory functions, influencing various cellular processes and signaling pathways. Its dysregulation has significant implications for human disease, highlighting the need for further research into the functional implications of MIR183.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.