Details for: PHKG1P3

Gene ID: 5262

Symbol: PHKG1P3

Ensembl ID: ENSG00000236919

Description: phosphorylase kinase catalytic subunit gamma 1 pseudogene 3

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.1243
    Cell Significance Index: 1.5700
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.0843
    Cell Significance Index: 0.9900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0240
    Cell Significance Index: -0.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PHKG1P3 is a pseudogene, meaning it has a similar sequence to an active gene but lacks the necessary regulatory elements to produce a functional protein. The pseudogene is located on chromosome 2 and has a homology to the PHKG1 gene, which encodes the gamma 1 subunit of phosphorylase kinase. PHKG1P3 is significantly expressed in stromal cells, which are a crucial component of various tissues, including bone, cartilage, and muscle. **Pathways and Functions:** The PHKG1P3 gene is likely involved in the regulation of glycogen metabolism, as it is located near the PHKG1 gene, which is a key enzyme in this process. Glycogen metabolism is essential for energy storage and release in cells. The gamma 1 subunit of phosphorylase kinase is responsible for the phosphorylation of glycogen, which triggers its breakdown. While PHKG1P3 is a pseudogene, it may still influence the regulation of glycogen metabolism through mechanisms such as gene regulation or protein-protein interactions. **Potential Pathways:** 1. **Glycogen Metabolism:** PHKG1P3 may regulate glycogen metabolism by modulating the expression of PHKG1 or other genes involved in this process. 2. **Stromal Cell Function:** PHKG1P3 may play a role in maintaining the function of stromal cells by regulating their metabolic activity, proliferation, or differentiation. 3. **Cell Signaling:** PHKG1P3 may be involved in cell signaling pathways, such as the PI3K/AKT pathway, which regulates various cellular processes, including metabolism and cell survival. **Clinical Significance:** The clinical significance of PHKG1P3 is still unclear, but its expression in stromal cells suggests that it may be involved in various diseases characterized by altered stromal cell function. For example: 1. **Osteoporosis:** PHKG1P3 may play a role in regulating bone remodeling and density, which is affected in osteoporosis. 2. **Muscle Diseases:** PHKG1P3 may influence muscle metabolism and function, which is impaired in various muscle diseases. 3. **Cancer:** PHKG1P3 may be involved in the regulation of stromal cell function and metabolism, which is altered in various types of cancer. In conclusion, while PHKG1P3 is a pseudogene, its significant expression in stromal cells suggests that it may have functional implications in cellular processes. Further research is needed to elucidate the mechanisms by which PHKG1P3 regulates glycogen metabolism and stromal cell function, as well as its clinical significance in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.