Details for: RNU1 4

Gene ID: 6060

Symbol: RNU1 4

Ensembl ID: ENSG00000207389

Description: RNA, U1 small nuclear 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0013
    Cell Significance Index: -0.0100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0025
    Cell Significance Index: -0.0400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0091
    Cell Significance Index: -0.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The RNU1 gene is a small, non-coding RNA molecule ( approximately 80 nucleotides in length) that is part of the U1 snRNP complex. This complex is composed of the RNU1 RNA, the U1 small nuclear protein A (U1 snRNP A), and the U1 small nuclear protein B (U1 snRNP B). The RNU1 RNA is essential for the recognition and binding of pre-mRNA 5'-splice sites, facilitating the splicing process that removes introns and joins exons to form mature mRNA. RNU1 is a highly conserved gene across species, suggesting its fundamental importance in cellular processes. Its expression is widespread, with notable presence in cells involved in immune responses, epithelial tissues, and hematopoietic cells. The gene's expression profile suggests a role in maintaining tissue homeostasis and immune regulation. **Pathways and Functions** The RNU1 gene is involved in the splicing of pre-mRNA, a critical step in the processing of RNA transcripts. The U1 snRNP complex, in which RNU1 is a key component, recognizes and binds to pre-mRNA 5'-splice sites, facilitating the removal of introns and the joining of exons. This process is essential for the production of mature mRNA, which is then translated into proteins. RNU1's involvement in splicing also extends to the regulation of alternative splicing, a process that allows for the production of multiple isoforms of a protein from a single gene. Alternative splicing is crucial for the generation of diverse immune responses and the regulation of cellular processes. **Clinical Significance** The RNU1 gene's role in immune regulation and tissue homeostasis has significant implications for the diagnosis and treatment of various diseases. Dysregulation of the U1 snRNP complex, including RNU1, has been implicated in several human disorders, including: 1. **Autoimmune diseases**: Alterations in RNU1 expression and function have been linked to autoimmune diseases, such as lupus and rheumatoid arthritis, where immune system dysregulation plays a key role. 2. **Cancer**: Changes in RNU1 expression have been observed in various types of cancer, suggesting its potential as a biomarker for diagnosis and prognosis. 3. **Immune-related disorders**: RNU1's role in regulating immune responses makes it a potential target for the treatment of immune-related disorders, such as inflammatory bowel disease and allergies. In conclusion, the RNU1 gene plays a critical role in the splicing of pre-mRNA and the regulation of alternative splicing, with significant implications for immune regulation and tissue homeostasis. Further research is needed to fully elucidate the gene's function and its role in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.