Details for: RNA5SP225

Gene ID: 100873484

Symbol: RNA5SP225

Ensembl ID: ENSG00000222806

Description: RNA, 5S ribosomal pseudogene 225

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0019
    Cell Significance Index: 0.0200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0012
    Cell Significance Index: -0.0100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0033
    Cell Significance Index: -0.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-coding RNA**: RNA5SP225 is a non-coding RNA molecule, meaning it does not encode proteins. Instead, it plays a regulatory role in gene expression and cellular processes. 2. **5S ribosomal pseudogene**: The RNA5SP225 gene is a member of the 5S ribosomal pseudogene family, which are non-coding RNAs that are closely linked to ribosomal genes. 3. **High expression in intestinal cells**: RNA5SP225 is highly expressed in various intestinal cell types, including enteric neurons, intestinal epithelial cells, goblet cells, and absorptive cells. 4. **Abnormal expression in neoplastic cells**: RNA5SP225 expression is also elevated in neoplastic cells, suggesting its potential involvement in tumorigenesis. **Pathways and Functions:** 1. **Regulation of gene expression**: RNA5SP225 may play a role in regulating gene expression by influencing the activity of nearby ribosomal genes or other non-coding RNAs. 2. **Cell differentiation and proliferation**: RNA5SP225 may be involved in the regulation of cellular differentiation and proliferation, particularly in enteric neurons and intestinal epithelial cells. 3. **Cell survival and apoptosis**: RNA5SP225 may also influence cell survival and apoptosis, potentially through interactions with other signaling pathways. 4. **MicroRNA regulation**: RNA5SP225 may be a target of microRNAs, which are small non-coding RNAs that regulate gene expression post-transcriptionally. **Clinical Significance:** 1. **Cancer diagnosis and prognosis**: Elevated RNA5SP225 expression in neoplastic cells may serve as a potential biomarker for cancer diagnosis and prognosis. 2. **Gastrointestinal disorders**: Abnormal RNA5SP225 expression in gastrointestinal disorders, such as inflammatory bowel disease or cancer, may provide insights into the underlying pathogenesis. 3. **Neurological disorders**: RNA5SP225 expression in enteric neurons may be involved in the regulation of neural function and behavior, potentially linking this gene to neurological disorders. 4. **Gene therapy and RNA-based therapies**: RNA5SP225 may be a target for gene therapy or RNA-based therapies aimed at modulating gene expression and cellular processes. In conclusion, the RNA5SP225 gene is a complex and multifunctional non-coding RNA molecule that plays a regulatory role in various cellular processes. Further research is needed to fully elucidate the functional role of RNA5SP225 and its clinical significance, but its high expression in intestinal cells and neoplastic cells suggests its potential as a biomarker or therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.