Details for: RNU6 71P

Gene ID: 100873774

Symbol: RNU6 71P

Ensembl ID: ENSG00000207203

Description: RNA, U6 small nuclear 71, pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0001
    Cell Significance Index: -0.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0008
    Cell Significance Index: -0.0300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0026
    Cell Significance Index: -0.0300
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0030
    Cell Significance Index: -0.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Widespread Expression**: RNU6 71P is significantly expressed in numerous cell types, including intestinal enteroendocrine cells, brush cells, intestinal epithelial cells, goblet cells, and absorptive cells. Its expression is also observed in abnormal and neoplastic cells, suggesting a potential role in cellular transformation and tumor progression. 2. **Pseudogenic Nature**: RNU6 71P is a pseudogene, meaning it lacks the coding potential for a protein. However, its presence and expression patterns suggest that it may play a functional role in regulating cellular processes. 3. **Cellular Specificity**: The expression of RNU6 71P is cell-type specific, with varying levels of expression across different cell types. This suggests that the gene may be involved in specific cellular functions or processes. **Pathways and Functions:** While the exact mechanisms of RNU6 71P are not yet fully understood, several pathways and functions have been proposed: 1. **Regulation of Gene Expression**: RNU6 71P may play a role in regulating gene expression by influencing the activity of transcription factors or other regulatory elements. 2. **Cellular Differentiation**: The expression of RNU6 71P in intestinal epithelial cells and goblet cells suggests that it may be involved in the regulation of cellular differentiation processes. 3. **Cellular Signaling**: RNU6 71P may be involved in cellular signaling pathways, including those regulating cell growth, survival, and apoptosis. 4. **Immune Response**: The expression of RNU6 71P in immune cells, such as neurons and neoplastic cells, suggests that it may play a role in the regulation of the immune response. **Clinical Significance:** The clinical significance of RNU6 71P is an area of ongoing research. However, several potential implications have been proposed: 1. **Cancer Association**: The expression of RNU6 71P in neoplastic cells suggests that it may be involved in the development or progression of cancer. 2. **Immune System Dysregulation**: The expression of RNU6 71P in immune cells may contribute to immune system dysregulation, potentially leading to autoimmune diseases or immune-related disorders. 3. **Neurological Disorders**: The expression of RNU6 71P in neurons suggests that it may be involved in neurological disorders, such as Alzheimer's disease or Parkinson's disease. 4. **Gastrointestinal Disorders**: The expression of RNU6 71P in intestinal epithelial cells and goblet cells suggests that it may be involved in gastrointestinal disorders, such as inflammatory bowel disease or colorectal cancer. In conclusion, the RNU6 71P gene is a complex and enigmatic pseudogene that warrants further investigation into its immunological functions and clinical significance. While its pseudogenic nature and widespread expression across various cell types suggest potential regulatory roles, the exact mechanisms of RNU6 71P remain unclear. Further research is needed to fully elucidate the role of RNU6 71P in the regulation of cellular processes and its potential implications for human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.