Details for: MPDU1 AS1

Gene ID: 100996842

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: MPDU1 AS1

Ensembl ID: ENSG00000233223

Description: MPDU1 antisense RNA 1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • bronchus fibroblast of lung CL2000093
    CSI 4.36
    rCSI 3.55%
    PRS 99.86
  • ciliated epithelial cell CL0000067
    CSI 3.99
    rCSI 3.5%
    PRS 99.38
  • microcirculation associated smooth muscle cell CL0008035
    CSI 1.11
    rCSI 3.22%
    PRS 99.92

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [MPDU1 AS1](/details-gene/100996842) is a non-coding antisense RNA located on chromosome 17p13.1. Expression data suggests a significant role within non-hematopoietic, structural cell types. **Overall**, it shows the highest significance in cells contributing to tissue architecture and function, such as [bronchus fibroblast of lung](/details-cell/CL2000093) and [ciliated epithelial cell](/details-cell/CL0000067), pointing towards potential involvement in pulmonary biology and tissue maintenance. ## Cellular Roles and Expression Landscape The expression profile of [MPDU1 AS1](/details-gene/100996842) indicates a specialized function in structural and mucosal cell populations. Its most significant expression is observed in [bronchus fibroblast of lung](/details-cell/CL2000093) (CSI: 4.36), suggesting a potential role in regulating the extracellular matrix or fibroblast activity within the lung. High significance is also noted in [ciliated epithelial cell](/details-cell/CL0000067) (CSI: 3.99), which are critical for mucociliary clearance in the respiratory tract. This association implies that [MPDU1 AS1](/details-gene/100996842) may be involved in the maintenance of ciliary function or epithelial integrity. A more moderate but notable significance in [microcirculation associated smooth muscle cell](/details-cell/CL0008035) (CSI: 1.11) further supports a role for this ncRNA in the maintenance of tissue structure, potentially related to vascular tone or integrity. The collective data points to a specialized function for [MPDU1 AS1](/details-gene/100996842) in the cellular biology of the lung and its associated vasculature. ## Pathways and Molecular Function The specific molecular functions and biological pathways associated with [MPDU1 AS1](/details-gene/100996842) are not detailed in the provided functional annotation data. As an antisense non-coding RNA, it may function by regulating the expression of its sense gene, MPDU1, or by interacting with chromatin-modifying complexes or RNA-binding proteins to influence gene expression programs in *trans*. Further research is required to elucidate its precise molecular mechanisms. ## Research Directions The specific expression pattern of [MPDU1 AS1](/details-gene/100996842) in lung structural cells suggests its potential involvement in respiratory physiology and pathology. **Proposed Hypotheses:** 1. Given its high significance in [bronchus fibroblast of lung](/details-cell/CL2000093), [MPDU1 AS1](/details-gene/100996842) may act as a regulator of fibroblast-to-myofibroblast differentiation and extracellular matrix deposition, potentially playing a role in the pathogenesis of pulmonary fibrosis. 2. The notable expression in [ciliated epithelial cell](/details-cell/CL0000067) suggests that [MPDU1 AS1](/details-gene/100996842) could be involved in regulating genes essential for ciliogenesis or the maintenance of ciliary motility, and its dysregulation could contribute to diseases characterized by impaired mucociliary clearance. **Experimental Approach:** To test the hypothesis that [MPDU1 AS1](/details-gene/100996842) regulates fibroblast function, one could perform loss-of-function studies in primary human bronchial fibroblasts. Cells could be transfected with antisense oligonucleotides (ASOs) or siRNAs targeting [MPDU1 AS1](/details-gene/100996842) and subsequently stimulated with a pro-fibrotic cytokine like TGF-β. The impact on myofibroblast differentiation could be quantified by measuring the expression of α-smooth muscle actin (ACTA2) via qPCR and Western blot, while changes in extracellular matrix production could be assessed by measuring collagen (e.g., COL1A1) expression and secretion. **Therapeutic Potential:** As a non-coding RNA, [MPDU1 AS1](/details-gene/100996842) could be a challenging yet promising therapeutic target. If it is shown to be a pro-fibrotic factor, its specific expression in lung fibroblasts could make it an attractive target for inhaled antisense oligonucleotide (ASO) therapies designed to inhibit its function. This strategy could potentially reduce fibrotic processes in diseases like idiopathic pulmonary fibrosis while minimizing systemic side effects. Therefore, inhibition would be the primary therapeutic strategy to explore.