Details for: LOC102724200

Gene ID: 102724200

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: LOC102724200

Ensembl ID: ENSG00000280433

Description: trafficking protein particle complex subunit 10-like

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 1.8
    rCSI 2.19%
    PRS 98.62

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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  • Node Color (Target Cell CSI, relative to current network):
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    • High
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    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [LOC102724200](/details-gene/102724200), known as trafficking protein particle complex subunit 10-like, is a protein-coding gene located on chromosome 21. Based on its nomenclature, it is predicted to be involved in intracellular vesicle-mediated transport. **Overall** expression data suggests a specialized role within the adaptive immune system, with its most significant expression signature observed in [CD8-positive, alpha-beta memory T cells, CD45RO-positive](/details-cell/CL0001203), indicating it may contribute to the maintenance or function of this specific T cell subset. ## Cellular Roles and Expression Landscape Analysis of the expression profile for [LOC102724200](/details-gene/102724200) points towards a focused role in a mature component of the cell-mediated immune system. * **T-Cell Specialization:** The available data highlights [LOC102724200](/details-gene/102724200) as a significant gene in [CD8-positive, alpha-beta memory T cells, CD45RO-positive](/details-cell/CL0001203) (CSI: 1.80). This specific cell type represents a subset of memory T cells that have previously encountered an antigen and are poised for a rapid secondary response. The notable expression in these cells suggests a potential function in processes essential for long-term T cell survival, memory maintenance, or rapid reactivation upon secondary antigen exposure. Further investigation is required to determine its expression across a broader range of immune and non-immune cell types to fully delineate its cellular specificity. ## Research Directions The specific enrichment of [LOC102724200](/details-gene/102724200) in a memory T cell subset, combined with its putative function in protein trafficking, opens several avenues for future research. ### Proposed Hypotheses: 1. **Role in Memory T Cell Homeostasis:** [LOC102724200](/details-gene/102724200) may be critical for the long-term survival and homeostatic maintenance of [CD8-positive, alpha-beta memory T cells, CD45RO-positive](/details-cell/CL0001203) by ensuring the proper functioning of vesicle trafficking pathways essential for nutrient receptor recycling or autophagy. 2. **Facilitation of Effector Function:** The gene could be involved in the rapid effector response of memory T cells. It may regulate the trafficking and deployment of cytotoxic granules or the secretion of key cytokines, such as IFN-gamma, following T cell receptor (TCR) restimulation. ### Experimental Approach: To test the hypothesis that [LOC102724200](/details-gene/102724200) is involved in memory T cell effector function, a functional genomics approach could be employed. * **Experiment:** Isolate [CD8-positive, alpha-beta memory T cells, CD45RO-positive](/details-cell/CL0001203) from healthy human donors. Utilize a CRISPR-Cas9 ribonucleoprotein (RNP) system to specifically knock out [LOC102724200](/details-gene/102724200). Following knockout, restimulate the cells *in vitro* with cognate peptide-MHC complexes or anti-CD3/CD28 antibodies. The impact on effector function can be quantified by measuring degranulation (via surface CD107a staining), cytokine production (via intracellular flow cytometry for IFN-gamma and TNF-alpha), and cytotoxic potential in a co-culture killing assay. A significant impairment in these functions in knockout cells compared to non-targeting controls would confirm its role in the memory T cell response. ### Therapeutic Potential: The therapeutic potential of [LOC102724200](/details-gene/102724200) is currently speculative. As an intracellular protein likely involved in a core trafficking pathway, it may be a challenging drug target due to the risk of systemic off-target effects. However, if its expression is highly restricted to specific T cell populations driving autoimmune diseases or certain cancers, and it proves to be a non-redundant hub for their function, it could emerge as a potential target for novel intracellular inhibitors. A comprehensive expression atlas and a deeper understanding of its specific molecular function are necessary first steps to evaluate this potential.