Details for: LOC105371789

Gene ID: 105371789

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: LOC105371789

Ensembl ID: ENSG00000267638

Description: uncharacterized LOC105371789

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • suprabasal keratinocyte CL4033013
    CSI 6.69
    rCSI 10.93%
    PRS 97.54
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 4.03
    rCSI 4.88%
    PRS 96.94

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [LOC105371789](/details-gene/105371789) is an uncharacterized long non-coding RNA (lncRNA) located on chromosome 17q21.31. **Overall** expression analysis indicates a highly specific expression pattern, with significant enrichment observed primarily in epithelial and immune cell compartments. Its high cell significance index (CSI) in [suprabasal keratinocytes](/details-cell/CL4033013) suggests a potential role in epidermal differentiation and skin barrier function. Additionally, its notable expression in [CD8-positive, alpha-beta memory T cells, CD45RO-positive](/details-cell/CL0001203) points towards a possible involvement in the maintenance or function of adaptive immune memory. The function of [LOC105371789](/details-gene/105371789) remains to be elucidated. ## Cellular Roles and Expression Landscape The expression profile of [LOC105371789](/details-gene/105371789) is characterized by its high specificity in a limited number of cell types. * **Epithelial Tissues:** The most significant expression is found in [suprabasal keratinocytes](/details-cell/CL4033013) (CSI: 6.69), which are keratinocytes undergoing terminal differentiation to form the outer layers of the epidermis. This strong and specific expression suggests that [LOC105371789](/details-gene/105371789) may be a key regulator in the process of skin stratification and barrier formation. * **Immune System:** A secondary but significant site of expression is within the memory T cell compartment, specifically in [CD8-positive, alpha-beta memory T cells, CD45RO-positive](/details-cell/CL0001203) (CSI: 4.03). This observation implies a potential function related to the long-term persistence, surveillance, or recall response of cytotoxic T lymphocytes. The dual-expression pattern in both skin and memory T cells is noteworthy, as both cell types are critically involved in the body's interface with the external environment and play roles in barrier defense and long-term antigen memory. ## Pathways and Molecular Function As an uncharacterized non-coding RNA, the molecular functions and associated biological pathways of [LOC105371789](/details-gene/105371789) are currently unknown. LncRNAs can function through diverse mechanisms, including epigenetic modulation, transcriptional regulation in *cis* or *trans*, and post-transcriptional control of mRNA stability or translation. Given its cellular expression context, it is plausible that [LOC105371789](/details-gene/105371789) interacts with chromatin-modifying complexes to regulate genes involved in keratinocyte differentiation or participates in signaling pathways essential for T cell memory maintenance. ## Research Directions The specific expression pattern of [LOC105371789](/details-gene/105371789) provides a clear basis for further investigation into its biological role, particularly in dermatology and immunology. **Proposed Hypotheses:** 1. [LOC105371789](/details-gene/105371789) functions as a critical regulator of terminal differentiation in keratinocytes. Its knockdown would be expected to impair the expression of key structural proteins (e.g., filaggrin, loricrin) and compromise epidermal barrier integrity. 2. In CD8+ memory T cells, [LOC105371789](/details-gene/105371789) is involved in maintaining the quiescent state or promoting rapid reactivation upon secondary antigen encounter. Its loss may lead to a decline in the memory T cell population or a dampened recall response. **Suggested Experimental Approach:** To test the hypothesis regarding its role in keratinocytes, a loss-of-function study could be performed. Specifically, one could use antisense oligonucleotides (ASOs) to knock down [LOC105371789](/details-gene/105371789) expression in primary human keratinocytes cultured in an organotypic 3D air-liquid interface model. The effects of the knockdown could be evaluated by assessing: (i) epidermal morphology and stratification via histology, (ii) expression of differentiation markers (e.g., Keratin 10, Involucrin, Loricrin) using qRT-PCR and immunofluorescence, and (iii) barrier function through transepidermal electrical resistance (TEER) measurements. **Therapeutic Potential:** The therapeutic potential of [LOC105371789](/details-gene/105371789) is highly speculative at this stage. However, if it is proven to be a master regulator of skin barrier formation, it could represent a novel therapeutic target for skin disorders characterized by barrier defects, such as atopic dermatitis or psoriasis. Modulating its expression, perhaps through topically applied ASOs, could offer a strategy to restore barrier function. Given its non-coding nature, activation or inhibition strategies would be plausible, depending on whether its dysregulation in disease involves loss or gain of function.