Details for: LOC105371856

Gene ID: 105371856

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: LOC105371856

Ensembl ID: ENSG00000226797

Description: uncharacterized LOC105371856

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • oligodendrocyte precursor cell CL0002453
    CSI 2.75
    rCSI 6.05%
    PRS 100
  • direct pathway medium spiny neuron CL4023026
    CSI 0.38
    rCSI 8.99%
    PRS 99.51
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.37
    rCSI 8.98%
    PRS 99.45

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [LOC105371856](/details-gene/105371856) is an uncharacterized non-coding RNA (ncRNA) located on human chromosome 17q23.3. While its molecular function remains unknown, expression data strongly indicates a specialized role within the central nervous system. Its most significant expression is observed in [oligodendrocyte precursor cell](/details-cell/CL0002453), suggesting a potential involvement in oligodendrocyte biology, such as proliferation, differentiation, or the regulation of myelination. Minor expression associations are also noted in neuronal subtypes, including [direct pathway medium spiny neuron](/details-cell/CL4023026) and [indirect pathway medium spiny neuron](/details-cell/CL4023029). ## Cellular Roles and Expression Landscape The expression profile of [LOC105371856](/details-gene/105371856) points towards a specific function in the development or maintenance of the central nervous system. * **Central Nervous System Specificity:** **Overall**, the gene's expression is predominantly linked to neural cell types. The most striking feature is its highly significant expression in [oligodendrocyte precursor cell](/details-cell/CL0002453) (CSI: 2.75). This strong association suggests that [LOC105371856](/details-gene/105371856) may function as a specific marker for this glial cell lineage or play an active role in its biological processes. * **Neuronal Association:** A weaker but notable expression is also detected in striatal neurons, specifically [direct pathway medium spiny neuron](/details-cell/CL4023026) (CSI: 0.38) and [indirect pathway medium spiny neuron](/details-cell/CL4023029) (CSI: 0.37). This suggests that while its primary role may be in glial cells, it could have secondary functions within specific neuronal circuits. Due to the limited scope of available data, the expression of [LOC105371856](/details-gene/105371856) in other tissues and cell lineages, or its potential for dynamic regulation across different biological contexts, is not yet characterized. ## Pathways and Molecular Function The functional role of [LOC105371856](/details-gene/105371856) remains uncharacterized, and it is not currently annotated in major functional databases such as the Gene Ontology (GO) or Reactome pathway databases. Based on its highly specific expression pattern, it is speculative that [LOC105371856](/details-gene/105371856) could participate in regulatory networks governing oligodendrocyte development. As an ncRNA, it might function by modulating the expression of key protein-coding genes involved in cell fate decisions, proliferation, or the initiation of myelination. ## Research Directions The specific expression of the uncharacterized ncRNA [LOC105371856](/details-gene/105371856) in [oligodendrocyte precursor cell](/details-cell/CL0002453) warrants further investigation, particularly concerning its potential role in CNS health and disease. **Proposed Hypotheses:** 1. [LOC105371856](/details-gene/105371856) acts as a regulatory checkpoint that maintains [oligodendrocyte precursor cell](/details-cell/CL0002453) in a proliferative, undifferentiated state. Its downregulation may be a prerequisite for their maturation into myelinating oligodendrocytes. 2. [LOC105371856](/details-gene/105371856) is directly involved in the transcriptional regulation of genes essential for myelin sheath formation, and its expression is upregulated as [oligodendrocyte precursor cell](/details-cell/CL0002453) commit to the oligodendrocyte lineage. **Experimental Approach:** To test the hypothesis that [LOC105371856](/details-gene/105371856) is a negative regulator of differentiation (Hypothesis 1), one could perform a loss-of-function study in primary human [oligodendrocyte precursor cell](/details-cell/CL0002453) cultured *in vitro*. Knockdown of [LOC105371856](/details-gene/105371856) could be achieved using antisense oligonucleotides (ASOs) or a CRISPR interference (CRISPRi) system. The impact on differentiation would be assessed by quantifying the expression of mature oligodendrocyte markers (e.g., MBP, PLP1) via qPCR and immunocytochemistry, alongside morphological analysis for the formation of complex, sheet-like structures characteristic of mature oligodendrocytes. **Therapeutic Potential:** Given its high specificity for [oligodendrocyte precursor cell](/details-cell/CL0002453), [LOC105371856](/details-gene/105371856) emerges as a potential therapeutic target for demyelinating diseases such as multiple sclerosis. If this ncRNA is proven to inhibit differentiation, its targeted **inhibition** via brain-penetrant ASOs could be a viable strategy to promote remyelination by unleashing the regenerative capacity of resident OPCs. Conversely, if it promotes OPC survival or proliferation, its **activation** could be explored as a means to expand the OPC pool available for repair.