Details for: WDR4

Gene ID: 10785

Symbol: WDR4

Ensembl ID: ENSG00000160193

Description: WD repeat domain 4

Associated with

Other Information

Genular Protein ID: 2779875623

Symbol: WDR4_HUMAN

Name: N/A

UniProtKB Accession Codes:

P57081 A8KA58 B2RCA3 B4DNQ7 D3DSK3 Q9BVM5 Q9HCR3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 5 EPD 1 Ensembl 2 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HAMAP 1 HAMAP-Rule 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 8 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10950928

Title: Isolation and characterization of a human chromosome 21q22.3 gene (WDR4) and its mouse homologue that code for a WD-repeat protein.

PubMed ID: 10950928

DOI: 10.1006/geno.2000.6258

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12403464

Title: Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA.

PubMed ID: 12403464

DOI: 10.1017/s1355838202024019

PubMed ID: 15861136

Title: The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells.

PubMed ID: 15861136

DOI: 10.1038/sj.emboj.7600648

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26751069

Title: Wuho is a new member in maintaining genome stability through its interaction with flap endonuclease 1.

PubMed ID: 26751069

DOI: 10.1371/journal.pbio.1002349

PubMed ID: 30079490

Title: Mutations in WDR4 as a new cause of Galloway-Mowat syndrome.

PubMed ID: 30079490

DOI: 10.1002/ajmg.a.40489

PubMed ID: 31031084

Title: Transcriptome-wide mapping of internal N7-methylguanosine methylome in mammalian mRNA.

PubMed ID: 31031084

DOI: 10.1016/j.molcel.2019.03.036

PubMed ID: 31031083

Title: METTL1 promotes let-7 microRNA processing via m7G methylation.

PubMed ID: 31031083

DOI: 10.1016/j.molcel.2019.03.040

PubMed ID: 34352207

Title: METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.

PubMed ID: 34352207

DOI: 10.1016/j.molcel.2021.06.031

PubMed ID: 34352206

Title: N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression.

PubMed ID: 34352206

DOI: 10.1016/j.molcel.2021.07.003

PubMed ID: 34371184

Title: METTL1/WDR4-mediated m7G tRNA modifications and m7G codon usage promote mRNA translation and lung cancer progression.

PubMed ID: 34371184

DOI: 10.1016/j.ymthe.2021.08.005

PubMed ID: 37379838

Title: QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism.

PubMed ID: 37379838

DOI: 10.1016/j.cell.2023.05.047

PubMed ID: 37369656

Title: Structural insight into how WDR4 promotes the tRNA N7-methylguanosine methyltransferase activity of METTL1.

PubMed ID: 37369656

DOI: 10.1038/s41421-023-00562-y

PubMed ID: 36599982

Title: Structures and mechanisms of tRNA methylation by METTL1-WDR4.

PubMed ID: 36599982

DOI: 10.1038/s41586-022-05565-5

PubMed ID: 36599985

Title: Structural basis of regulated m7G tRNA modification by METTL1-WDR4.

PubMed ID: 36599985

DOI: 10.1038/s41586-022-05566-4

PubMed ID: 26416026

Title: Mutation in WDR4 impairs tRNA m(7)G46 methylation and causes a distinct form of microcephalic primordial dwarfism.

PubMed ID: 26416026

DOI: 10.1186/s13059-015-0779-x

PubMed ID: 29597095

Title: Speech and language delay in a patient with WDR4 mutations.

PubMed ID: 29597095

DOI: 10.1016/j.ejmg.2018.03.007

PubMed ID: 28617965

Title: Further delineation of the phenotype caused by biallelic variants in the WDR4 gene.

PubMed ID: 28617965

DOI: 10.1111/cge.13074

Sequence Information:

  • Length: 412
  • Mass: 45490
  • Checksum: 394B11A2AFB1CADB
  • Sequence:
    • MAGSVGLALC GQTLVVRGGS RFLATSIASS DDDSLFIYDC SAAEKKSQEN KGEDAPLDQG 
SGAILASTFS KSGSYFALTD DSKRLILFRT KPWQCLSVRT VARRCTALTF IASEEKVLVA 
DKSGDVYSFS VLEPHGCGRL ELGHLSMLLD VAVSPDDRFI LTADRDEKIR VSWAAAPHSI 
ESFCLGHTEF VSRISVVPTQ PGLLLSSSGD GTLRLWEYRS GRQLHCCHLA SLQELVDPQA 
PQKFAASRIA FWCQENCVAL LCDGTPVVYI FQLDARRQQL VYRQQLAFQH QVWDVAFEET 
QGLWVLQDCQ EAPLVLYRPV GDQWQSVPES TVLKKVSGVL RGNWAMLEGS AGADASFSSL 
YKATFDNVTS YLKKKEERLQ QQLEKKQRRR SPPPGPDGHA KKMRPGEATL SC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.