Details for: VSIG10L

Gene ID: 147645

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: VSIG10L

Ensembl ID: ENSG00000186806

Description: V-set and immunoglobulin domain containing 10 like

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • squamous epithelial cell CL0000076
    CSI 2.67
    rCSI 6.34%
    PRS 99.6
  • epithelial cell of esophagus CL0002252
    CSI 0.69
    rCSI 6.87%
    PRS 99.86

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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  • Node Color (Target Cell CSI, relative to current network):
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    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [VSIG10L](/details-gene/147645) (V-set and immunoglobulin domain containing 10 like) is a protein-coding gene located on human chromosome 19q13.41 ([Link](https://pubmed.ncbi.nlm.nih.gov/15057824/)). It encodes a protein featuring V-set and immunoglobulin domains, suggesting a role in cell-cell recognition, adhesion, or signaling. **Overall** expression analysis indicates that [VSIG10L](/details-gene/147645) is a highly significant marker for specific epithelial tissues, with its most prominent expression observed in [squamous epithelial cell](/details-cell/CL0000076)s and [epithelial cell of esophagus](/details-cell/CL0002252). Research has implicated germline mutations in this gene with an increased risk for familial Barrett neoplasia ([Link](https://doi.org/10.1001/jamaoncol.2016.2054)). ## Cellular Roles and Expression Landscape The expression profile of [VSIG10L](/details-gene/147645) points towards a specialized function within stratified epithelial tissues. **Overall**, the gene demonstrates its highest significance in [squamous epithelial cell](/details-cell/CL0000076) (CSI: 2.67), a finding that is strongly reinforced by its notable expression in the anatomically related [epithelial cell of esophagus](/details-cell/CL0002252) (CSI: 0.69). This co-expression pattern suggests that [VSIG10L](/details-gene/147645) is likely integral to the identity and function of the esophageal lining and other squamous epithelia. The lack of significant expression in other major cell lineages suggests a highly specific role, likely confined to this cellular context. ## Pathways and Molecular Function The functional annotation for [VSIG10L](/details-gene/147645) provides broad insights into its subcellular localization. Gene Ontology terms associate the protein with the [Membrane](/details-go/GO:0016020) and the [Nucleoplasm](/details-go/GO:0005654). The V-set and immunoglobulin domains, coupled with the membrane localization, are consistent with a function as a cell surface receptor or adhesion molecule, which would align with its role in maintaining epithelial tissue structure. The nucleoplasm annotation is less expected for a V-set domain protein and may suggest an alternative splice variant or a yet-undescribed role in nuclear processes or signaling. ## Research Directions The association between germline mutations in [VSIG10L](/details-gene/147645) and familial Barrett neoplasia, a precursor to esophageal adenocarcinoma, positions this gene as a potentially critical player in epithelial homeostasis and tumor suppression ([Link](https://doi.org/10.1001/jamaoncol.2016.2054)). This clinical finding, combined with its specific expression in esophageal epithelial cells, warrants further investigation into its molecular mechanism. **Testable Hypotheses:** 1. Loss-of-function mutations in [VSIG10L](/details-gene/147645) disrupt cell-cell adhesion and compromise the barrier integrity of the esophageal epithelium, creating a microenvironment permissive for metaplasia in response to chronic insults like acid reflux. 2. [VSIG10L](/details-gene/147645) functions as a cell surface receptor that, upon ligand binding, initiates an intracellular signaling cascade that promotes normal epithelial differentiation and suppresses proliferation. Mutations may abrogate this signaling, leading to uncontrolled cell growth. **Proposed Experimental Approach:** To test the first hypothesis, CRISPR-Cas9 could be used to knock out [VSIG10L](/details-gene/147645) in a non-transformed human esophageal epithelial cell line (e.g., HET-1A). The functional consequences could then be assessed by comparing knockout cells to isogenic wild-type controls. Key experiments would include: i) immunofluorescence staining for junctional proteins (e.g., E-cadherin, occludin) to evaluate cell junction integrity; ii) transepithelial electrical resistance (TEER) assays to directly measure epithelial barrier function; and iii) scratch-wound or transwell migration assays to determine if loss of [VSIG10L](/details-gene/147645) promotes a more migratory, dysplastic phenotype. **Therapeutic Potential:** Given that existing evidence links loss-of-function mutations to a cancer predisposition syndrome, [VSIG10L](/details-gene/147645) appears to function as a tumor suppressor. This makes it a challenging direct therapeutic target, as strategies would need to focus on restoring its function rather than inhibiting it. However, its high tissue specificity makes it a valuable biomarker for risk stratification in families with a history of Barrett's esophagus. Furthermore, understanding the pathways downstream of [VSIG10L](/details-gene/147645) could reveal more druggable nodes that could be targeted to compensate for its loss in at-risk individuals.

Genular Protein ID: 2314351194

Symbol: VS10L_HUMAN

Name: V-set and immunoglobulin domain-containing protein 10-like

UniProtKB Accession Codes:

Q86VR7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMART 2 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 27467440

Title: Association between germline mutation in VSIG10L and familial Barrett neoplasia.

PubMed ID: 27467440

DOI: 10.1001/jamaoncol.2016.2054

Sequence Information:

  • Length: 867
  • Mass: 91625
  • Checksum: 422D87D82E44E597
  • Sequence:
    • MDNPQALPLF LLLASLVGIL TLRASSGLQQ TNFSSAFSSD SKSSSQGLGV EVPSIKPPSW 
KVPDQFLDSK ASAGISDSSW FPEALSSNMS GSFWSNVSAE GQDLSPVSPF SETPGSEVFP 
DISDPQVPAK DPKPSFTVKT PASNISTQVS HTKLSVEAPD SKFSPDDMDL KLSAQSPESK 
FSAETHSAAS FPQQVGGPLA VLVGTTIRLP LVPIPNPGPP TSLVVWRRGS KVLAAGGLGP 
GAPLISLDPA HRDHLRFDQA RGVLELASAQ LDDAGVYTAE VIRAGVSQQT HEFTVGVYEP 
LPQLSVQPKA PETEEGAAEL RLRCLGWGPG RGELSWSRDG RALEAAESEG AETPRMRSEG 
DQLLIVRPVR SDHARYTCRV RSPFGHREAA ADVSVFYGPD PPTITVSSDR DAAPARFVTA 
GSNVTLRCAA ASRPPADITW SLADPAEAAV PAGSRLLLPA VGPGHAGTYA CLAANPRTGR 
RRRSLLNLTV ADLPPGAPQC SVEGGPGDRS LRFRCSWPGG APAASLQFQG LPEGIRAGPV 
SSVLLAAVPA HPRLSGVPIT CLARHLVATR TCTVTPEAPR EVLLHPLVAE TRLGEAEVAL 
EASGCPPPSR ASWAREGRPL APGGGSRLRL SQDGRKLHIG NFSLDWDLGN YSVLCSGALG 
AGGDQITLIG PSISSWRLQR ARDAAVLTWD VERGALISSF EIQAWPDGPA LGRTSTYRDW 
VSLLILGPQE RSAVVPLPPR NPGTWTFRIL PILGGQPGTP SQSRVYRAGP TLSHGAIAGI 
VLGSLLGLAL LAVLLLLCIC CLCRFRGKTP EKKKHPSTLV PVVTPSEKKM HSVTPVEISW 
PLDLKVPLED HSSTRAYQAQ TPVQLSL