Details for: CYP2D7

Gene ID: 1564

Symbol: CYP2D7

Description: cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)

Associated with

Other Information

Genular Protein ID: 2161836065

Symbol: CP2D7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X1C5 Q6XP50

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 ChEBI 10 ChEMBL 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 InParanoid 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OMA 1 PANTHER 2 PRINTS 3 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 Pharos 1 Proteomes 1 RNAct 1 RefSeq 1 Rhea 3 RuleBase 1 SMR 1 SUPFAM 1 UCSC 1 UniProtKB 1 VEuPathDB 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15051713

Title: A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.

PubMed ID: 15051713

DOI: 10.1074/jbc.m402337200

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 16169517

Title: CYP2D7 splice variants in human liver and brain: does CYP2D7 encode functional protein?

PubMed ID: 16169517

DOI: 10.1016/j.bbrc.2005.08.255

PubMed ID: 17494644

Title: Frequency of the frame-shifting CYP2D7 138delT polymorphism in a large, ethnically diverse sample population.

PubMed ID: 17494644

DOI: 10.1124/dmd.107.014993

PubMed ID: 18838503

Title: Expression and functional analysis of CYP2D6.24, CYP2D6.26, CYP2D6.27, and CYP2D7 isozymes.

PubMed ID: 18838503

DOI: 10.1124/dmd.108.023663

Sequence Information:

  • Length: 515
  • Mass: 57489
  • Checksum: E9331B1589161E03
  • Sequence:
    • MGLEALVPLA MIVAIFLLLV DLMHRHQRWA ARYPPGPLPL PGLGNLLHVD FQNTPYCFDQ 
LRRRFGDVFS LQLAWTPVVV LNGLAAVREA MVTRGEDTAD RPPAPIYQVL GFGPRSQGVI 
LSRYGPAWRE QRRFSVSTLR NLGLGKKSLE QWVTEEAACL CAAFADQAGR PFRPNGLLDK 
AVSNVIASLT CGRRFEYDDP RFLRLLDLAQ EGLKEESGFL REVLNAVPVL PHIPALAGKV 
LRFQKAFLTQ LDELLTEHRM TWDPAQPPRD LTEAFLAKKE KAKGSPESSF NDENLRIVVG 
NLFLAGMVTT STTLAWGLLL MILHLDVQRG RRVSPGCPIV GTHVCPVRVQ QEIDDVIGQV 
RRPEMGDQAH MPCTTAVIHE VQHFGDIVPL GVTHMTSRDI EVQGFRIPKG TTLITNLSSV 
LKDEAVWKKP FRFHPEHFLD AQGHFVKPEA FLPFSAGRRA CLGEPLARME LFLFFTSLLQ 
HFSFSVAAGQ PRPSHSRVVS FLVTPSPYEL CAVPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.