Details for: OR4F3

Gene ID: 26683

Symbol: OR4F3

Ensembl ID: ENSG00000230178

Description: olfactory receptor family 4 subfamily F member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.0024
    Cell Significance Index: 0.0300
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0017
    Cell Significance Index: 0.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0000
    Cell Significance Index: -0.0200
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0029
    Cell Significance Index: -0.0300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0044
    Cell Significance Index: -0.0300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0047
    Cell Significance Index: -0.0400
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0056
    Cell Significance Index: -0.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Olfactory receptor classification:** OR4F3 belongs to the olfactory receptor family 4 subfamily F, which is one of the 400-600 functional olfactory receptors estimated to exist in humans. 2. **G protein-coupled receptor (GPCR) structure:** OR4F3 is a GPCR, characterized by a seven-transmembrane domain structure that allows it to interact with olfactory receptors and transmit signals to downstream effectors. 3. **Chemical specificity:** OR4F3 has been shown to be specific for detecting certain odorant molecules, such as 2,5-dimethylpyrazine, which is a component of many foods and beverages. 4. **Expression in various cell types:** OR4F3 is expressed in multiple cell types, including glutamatergic neurons, Cajal-Retzius cells, and microglial cells, indicating its involvement in various neural processes. **Pathways and Functions:** 1. **Olfactory signaling pathway:** OR4F3 is involved in the detection of chemical stimuli and the transduction of olfactory signals from the olfactory epithelium to the central nervous system. 2. **G protein-coupled receptor signaling pathway:** OR4F3 activates G proteins, which in turn activate downstream effectors, such as adenylyl cyclase, to generate second messengers that regulate various cellular processes. 3. **Sensory perception:** OR4F3 plays a critical role in the perception of smell, allowing individuals to detect and distinguish between different odorant molecules. 4. **Neurotransmitter regulation:** OR4F3 has been shown to modulate the release of neurotransmitters, such as glutamate and GABA, which are involved in various neural processes, including learning and memory. **Clinical Significance:** 1. **Olfactory disorders:** OR4F3 variants have been associated with olfactory disorders, such as anosmia (loss of smell) and hyposmia (reduced smell). 2. **Neurodegenerative diseases:** Alterations in OR4F3 expression and function have been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** OR4F3 has been implicated in the development and progression of certain cancers, including breast and prostate cancer. 4. **Pharmacological applications:** OR4F3 has been identified as a potential target for the development of new olfactory-based therapies and treatments for olfactory disorders. In conclusion, the OR4F3 gene plays a crucial role in the detection of chemical stimuli and the transduction of olfactory signals, highlighting its importance in the perception of smell and the regulation of various neural processes. Further research is needed to fully elucidate the functions and clinical significance of OR4F3, but its potential as a therapeutic target and diagnostic marker for olfactory disorders makes it an exciting area of investigation.

Genular Protein ID: 3232607764

Symbol: OR4F3_HUMAN

Name: Olfactory receptor 4F3/4F16/4F29

UniProtKB Accession Codes:

Q6IEY1 B2RPQ6

Database IDs:

AGR 3 AlphaFoldDB 1 Antibodypedia 3 Bgee 1 BioGRID 3 BioGRID-ORCS 3 BioMuta 1 CCDS 3 CDD 1 CTD 3 DMDM 1 DNASU 1 EMBL 3 Ensembl 3 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 3 GeneTree 1 GeneWiki 2 GlyCosmos 1 GlyGen 1 HGNC 3 HOGENOM 1 HPA 3 InParanoid 1 IntAct 1 InterPro 4 KEGG 3 MANE-Select 3 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 2 RNAct 1 Reactome 1 RefSeq 8 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 3 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14983052

Title: The human olfactory receptor gene family.

PubMed ID: 14983052

DOI: 10.1073/pnas.0307882100

Sequence Information:

  • Length: 312
  • Mass: 35074
  • Checksum: 08285B196DC638FB
  • Sequence:
    • MDGENHSVVS EFLFLGLTHS WEIQLLLLVF SSVLYVASIT GNILIVFSVT TDPHLHSPMY 
FLLASLSFID LGACSVTSPK MIYDLFRKRK VISFGGCIAQ IFFIHVVGGV EMVLLIAMAF 
DRYVALCKPL HYLTIMSPRM CLSFLAVAWT LGVSHSLFQL AFLVNLAFCG PNVLDSFYCD 
LPRLLRLACT DTYRLQFMVT VNSGFICVGT FFILLISYVF ILFTVWKHSS GGSSKALSTL 
SAHSTVVLLF FGPPMFVYTR PHPNSQMDKF LAIFDAVLTP FLNPVVYTFR NKEMKAAIKR 
VCKQLVIYKR IS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.