Details for: AMYP1

Gene ID: 281

Symbol: AMYP1

Ensembl ID: ENSG00000227408

Description: amylase alpha pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.7978
    Cell Significance Index: 477.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4674
    Cell Significance Index: 68.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1592
    Cell Significance Index: 18.2400
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.0284
    Cell Significance Index: 0.3600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0066
    Cell Significance Index: -0.0600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0081
    Cell Significance Index: -0.1100
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0110
    Cell Significance Index: -0.1000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0114
    Cell Significance Index: -0.1100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0134
    Cell Significance Index: -0.1200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0151
    Cell Significance Index: -0.0900
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0157
    Cell Significance Index: -0.1300
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0188
    Cell Significance Index: -0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0198
    Cell Significance Index: -37.3500
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0230
    Cell Significance Index: -0.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0240
    Cell Significance Index: -3.4900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1931
    Cell Significance Index: -2.2100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2300
    Cell Significance Index: -2.1800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.2354
    Cell Significance Index: -2.2100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3203
    Cell Significance Index: -7.0100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.3645
    Cell Significance Index: -3.4600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.5215
    Cell Significance Index: -6.5800
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.5410
    Cell Significance Index: -6.1400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.6839
    Cell Significance Index: -11.5000
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.7021
    Cell Significance Index: -8.4300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.8847
    Cell Significance Index: -10.5800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.8926
    Cell Significance Index: -9.5700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.9036
    Cell Significance Index: -11.4300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -1.3722
    Cell Significance Index: -18.9700
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -1.6947
    Cell Significance Index: -21.1700
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -1.7874
    Cell Significance Index: -20.1400
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -1.7881
    Cell Significance Index: -20.2800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -2.1354
    Cell Significance Index: -26.2500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -2.1433
    Cell Significance Index: -25.5500
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -2.8090
    Cell Significance Index: -35.1800
  • Cell Name: T cell (CL0000084)
    Fold Change: -2.8741
    Cell Significance Index: -33.9300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -2.9150
    Cell Significance Index: -32.9300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -2.9970
    Cell Significance Index: -34.4900
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -3.5040
    Cell Significance Index: -46.5600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -3.5536
    Cell Significance Index: -43.0800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -4.5203
    Cell Significance Index: -34.7800
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -5.6984
    Cell Significance Index: -50.2000
  • Cell Name: macrophage (CL0000235)
    Fold Change: -6.3903
    Cell Significance Index: -65.2400
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -7.3383
    Cell Significance Index: -68.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** AMYP1 is classified as a pseudogene due to its lack of a functional coding sequence, which is a hallmark of non-functional genes. 2. **Expression patterns:** AMYP1 is significantly expressed in various cell types, including pancreatic acinar cells, salivary gland acinar cells, pancreatic ductal cells, astrocytes, neutrophils, duct epithelial cells, CD8-positive T cells, alpha-beta T cells, stromal cells, retinal rod cells, and macrophages. 3. **Evolutionary history:** The AMYP1 gene has undergone significant evolution, with multiple copies of the gene found in different species, suggesting a complex history of gene duplication and divergence. **Pathways and Functions:** 1. **Regulation of gene expression:** The non-coding RNA encoded by AMYP1 may play a role in regulating gene expression, possibly by influencing chromatin structure or interacting with transcription factors. 2. **Cellular differentiation:** AMYP1 expression has been linked to cellular differentiation, with the gene playing a role in the development of pancreatic acinar cells and retinal rod cells. 3. **Immune response:** AMYP1 is expressed in immune cells, such as neutrophils and macrophages, suggesting a potential role in the regulation of immune responses. **Clinical Significance:** 1. **Pancreatic disease:** AMYP1 expression has been linked to pancreatic disease, including pancreatitis and pancreatic cancer, suggesting a potential role in the development of these conditions. 2. **Neurological disorders:** The expression of AMYP1 in astrocytes and retinal rod cells raises the possibility of a link between this gene and neurological disorders, such as Alzheimer's disease and retinitis pigmentosa. 3. **Cancer biology:** The presence of AMYP1 in cancer cells highlights its potential role in cancer biology, including tumor progression and metastasis. In conclusion, the AMYP1 gene is a complex and multifaceted gene that has garnered significant attention in the scientific community. Further research is needed to fully elucidate the functions and clinical significance of this gene, but its intriguing expression patterns and potential implications in human health make it an exciting area of study.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.